Cholinergic modulation in the olfactory bulb influences spontaneous olfactory discrimination in adult rats
| Autor: | Christiane Linster, Casara Jean Ferretti, Daniel B. Rubin, Thomas A. Cleland, Conor Stack, Nathalie Mandairon |
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| Přispěvatelé: | Cornell University [New York] |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Male
[SDV]Life Sciences [q-bio] Action Potentials Olfaction Muscarinic Antagonists Nicotinic Antagonists Receptors Nicotinic Synaptic Transmission Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Mecamylamine medicine Animals Nicotinic Antagonist ComputingMilieux_MISCELLANEOUS 030304 developmental biology Neurons 0303 health sciences Afferent Pathways Chemistry General Neuroscience Muscarinic acetylcholine receptor M2 Olfactory Bulb Receptors Muscarinic Acetylcholine Olfactory bulb Rats Smell Nicotinic agonist Cholinergic Fibers Odorants Cholinergic Septal Nuclei [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Cholinesterase Inhibitors Neuroscience psychological phenomena and processes 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | European Journal of Neuroscience European Journal of Neuroscience, Wiley, 2006, 24 (11), pp.3234-3244. ⟨10.1111/j.1460-9568.2006.05212.x⟩ |
| ISSN: | 0953-816X 1460-9568 |
| DOI: | 10.1111/j.1460-9568.2006.05212.x⟩ |
| Popis: | Cholinergic neuromodulation in the olfactory bulb has been hypothesized to regulate mitral cell molecular receptive ranges and the behavioral discrimination of similar odorants. We tested the effects of cholinergic modulation in the olfactory bulb of cannulated rats by bilaterally infusing cholinergic agents into the olfactory bulbs and measuring the rats' performances on separate spontaneous and motivated odor-discrimination tasks. Specifically, 6 microL/bulb infusions of vehicle (0.9% saline), the muscarinic antagonist scopolamine (7.6 mM and 38 mM), the nicotinic antagonist mecamylamine hydrochloride (3.8 mM and 19 mM), a combination of both antagonists, or the acetylcholinesterase inhibitor neostigmine (8.7 mM) were made 20 min prior to testing on an olfactory cross-habituation task or a rewarded, forced-choice odor-discrimination task. Spontaneous discrimination between chemically related odorants was abolished when nicotinic receptors were blocked in the olfactory bulb, and enhanced when the efficacy of cholinergic inputs was increased with neostigmine. Blocking muscarinic receptors reduced but did not abolish odor discrimination. Interestingly, no behavioral effects of modulating either nicotinic or muscarinic receptors were observed when rats were trained on a reward-motivated odor-discrimination task. Computational modeling of glomerular circuitry demonstrates that known nicotinic cholinergic effects on bulbar neurons suffice to explain these results. |
| Databáze: | OpenAIRE |
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