The type III secretion system needle, tip, and translocon
| Autor: | Pallavi Guha Biswas, Supratim Dey, Amritangshu Chakravarty, Roberto N. De Guzman |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Models
Molecular Virulence Reviews Biochemistry Type three secretion system 03 medical and health sciences Bacterial Proteins Drug Resistance Bacterial Gram-Negative Bacteria Extracellular Type III Secretion Systems Animals Humans Molecular Biology 030304 developmental biology 0303 health sciences biology Chemistry 030302 biochemistry & molecular biology Structural component biochemical phenomena metabolism and nutrition biology.organism_classification Translocon bacterial infections and mycoses Cell biology Multiprotein Complexes bacteria Bacteria |
| Zdroj: | Protein Sci |
| Popis: | Many Gram-negative bacteria pathogenic to plants and animals deploy the type III secretion system (T3SS) to inject virulence factors into their hosts. All bacteria that rely on the T3SS to cause infectious diseases in humans have developed antibiotic resistance. The T3SS is an attractive target for developing new antibiotics because it is essential in virulence, and part of its structural component is exposed on the bacterial surface. The structural component of the T3SS is the needle apparatus, which is assembled from over 20 different proteins and consists of a base, an extracellular needle, a tip, and a translocon. This review summarizes the current knowledge on the structure and assembly of the needle, tip, and translocon. |
| Databáze: | OpenAIRE |
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