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Objective: West Nile Virus (WNV), which causes widespread outbreaks in different partsof the world, is a risk to public health in Turkey, too. Community-based study data areneeded to identify measures against possible outbreaks. This study aimed to determine theseroprevalence of community-based WNV in Manisa and to investigate the relationshipbetween sociodemographic and socioeconomic variables.Methods: We included individuals older than two years of age (n = 1,317,917) registered inthe Manisa Province Family Medicine Information System. Selected participants (n= 1233)were determined by a simple random sampling method. Specific IgG antibodies againstWNV were investigated in serum samples using a commercial ELISA test (Euroimmun,Germany). The relationship between age, gender, location, education and income level, occupation,population density, altitude, the location of the toilet in the house, and the presenceof hypertension, diabetes mellitus and cardiovascular disease variables were analyzedby chi-square, Fisher’s exact test and t-test. Adjusted odds ratio (OR) with 95% confidenceinterval (CI) for each variable were calculated by the logistic regression method to explainpotential risks.Results: WNV IgG antibodies were detected in 47 (3.8%) sera samples by ELISA.Seroprevalence was significantly correlated with independent variables of advanced age,presence of hypertension, diabetes mellitus and cardiovascular disease, low level of educationand income, living in low altitude areas and the location of the toilet. In multivariateanalysis; age (every one-year increase) (OR: 1.05; 95% CI: 1.02-1.07; p annual income per capita below 3265 TL (OR: 3.21; 95% CI: 1.53-6.73; p = 0.002), and livingareas below 132 meters altitude (OR = 3.21; 95% CI 1.26-8.15; p = 0.014) were found to be therisk factors for WNV seropositivity.Conclusion: In Manisa province, WNV IgG seroprevalence was detected as 3.8% with ELISAmethod. Older age, low income and living in regions with a low altitude were found to beassociated with increased seropositivity significantly.Keywords: West Nile virus, seroprevalence, ELISA |
