Widespread white matter aberration is associated with the severity of apathy in amnestic Mild Cognitive Impairment : tract-based spatial statistics analysis
| Autor: | André Aleman, Shankar Tumati, Fransje E. Reesink, Peter Paul De Deyn, Jan-Bernard C Marsman, Branislava Ćurčić-Blake, Tania M Setiadi, Sander Martens, Esther M. Opmeer |
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| Přispěvatelé: | Clinical Cognitive Neuropsychiatry Research Program (CCNP), Perceptual and Cognitive Neuroscience (PCN), Molecular Neuroscience and Ageing Research (MOLAR), Clinical Neuropsychology |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
IFOF
Inferior fronto-occipital fasciculus MMSE Mini mental state examination Audiology Corpus callosum Tract-based spatial statistics lcsh:RC346-429 aMCI amnestic Mild Cognitive Impairment ATR Anterior thalamic radiation 0302 clinical medicine FSL Functional MRI of the Brain (FMRIB) Software Library BNT Boston naming test VTA Ventral tegmental area Cingulum (brain) Medicine Arcuate fasciculus Apathy CC Corpus callosum FA Fractional anisotropy AES Apathy evaluation scale biology musculoskeletal neural and ocular physiology DS Digit Span 05 social sciences Brain Regular Article GDS Geriatric depression scale AD Alzheimer’s Disease White Matter medicine.anatomical_structure Diffusion tensor imaging Neurology OFC Orbitofrontal cortex Goal-directed behavior lcsh:R858-859.7 medicine.symptom psychological phenomena and processes CST Corticospinal tract medicine.medical_specialty Cognitive Neuroscience ACR Anterior corona radiata UF Uncinate fasciculus Uncinate fasciculus DTI Diffusion tensor imaging macromolecular substances lcsh:Computer applications to medicine. Medical informatics behavioral disciplines and activities 050105 experimental psychology NPS Neuropsychiatric symptoms 03 medical and health sciences SDMT Symbol digit modalities test TMT Trail making test Fasciculus Fractional anisotropy mental disorders Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Cognitive Dysfunction Inferior longitudinal fasciculus VS Ventral striatum lcsh:Neurology. Diseases of the nervous system SCR Superior corona radiata business.industry amnestic Mild Cognitive Impairment biology.organism_classification LPC Lateral parietal cortex TFCE Threshold-free cluster enhancement nervous system Anisotropy Neurology (clinical) RAVLT Rey auditory verbal learning test Human medicine ACC Anterior cingulate cortex business SLF Superior longitudinal fasciculus TBSS Tract-based spatial statistics 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage: Clinical NeuroImage. Clinical, 29:102567. ELSEVIER SCI LTD NeuroImage : Clinical NeuroImage: Clinical, Vol 29, Iss, Pp 102567-(2021) |
| ISSN: | 2213-1582 |
| Popis: | Highlights • In aMCI, apathy severity was associated with lower FA in widespread WM pathways. • WM aberrations are related to apathy severity after controlling for depression. • Disruptions related to apathy severity are not limited to frontal-subcortical area. Apathy is recognized as a prevalent behavioral symptom of amnestic Mild Cognitive Impairment (aMCI). In aMCI, apathy is associated with an increased risk and increases the risk of progression to Alzheimer’s Disease (AD). Previous DTI study in aMCI showed that apathy has been associated with white matter alterations in the cingulum, middle and inferior longitudinal fasciculus, fornix, and uncinate fasciculus. However, the underlying white matter correlates associated with apathy in aMCI are still unclear. We investigated this relationship using whole-brain diffusion tensor imaging (DTI). Twenty-nine aMCI patients and 20 matched cognitively healthy controls were included. Apathy severity was assessed using the Apathy Evaluation Scale Clinician version. We applied the tract-based spatial statistics analyses to DTI parameters: fractional anisotropy (FA), mean diffusivity, axial diffusivity, and radial diffusivity to investigate changes in white matter pathways associated with the severity of apathy. No significant difference was found in any of the DTI parameters between aMCI and the control group. In aMCI, higher severity of apathy was associated with lower FA in various white matter pathways including the left anterior part of inferior fronto-occipital fasciculus/uncinate fasciculus, genu and body of the corpus callosum, superior and anterior corona radiata, anterior thalamic radiation of both hemispheres and in the right superior longitudinal fasciculus/anterior segment of arcuate fasciculus (p |
| Databáze: | OpenAIRE |
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