Effect of tPA on regional lung perfusion in unilobar canine pulmonary thromboembolism
| Autor: | Akiteru Yoshikawa, Seiki Nakatani, Mizuho Nosaka, Hidenao Takata, Hirotomi Tanaka, Takeshi Ikeda, Susumu Yukawa |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Pulmonary Circulation Hemodynamics Blood Pressure Pulmonary Artery Critical Care and Intensive Care Medicine Electrocardiography Plasminogen Activators Dogs medicine.artery medicine Animals Bronchus Lung biology Vascular disease business.industry Pulmonary Gas Exchange Fissipedia Respiratory disease Blood flow Carbon Dioxide medicine.disease biology.organism_classification Surgery medicine.anatomical_structure Tissue Plasminogen Activator Pulmonary artery Nuclear medicine business Pulmonary Embolism |
| Zdroj: | American journal of respiratory and critical care medicine. 156(5) |
| ISSN: | 1073-449X |
| Popis: | We investigated effects of tissue-type plasminogen activator (tPA) on regional pulmonary arterial hemodynamics in pulmonary thromboembolism (PTE) in a canine model of unilobar PTE. Ten beagle dogs were divided into two groups-tPA (n = 5) and control group (n = 5). In each dog an artificial blood circuit (ABC) consisting of a silicone tube and a cannulation-type electromagnetic blood flowmeter probe was placed at the left lower pulmonary artery. A unilobar PTE was induced by placing autologous clots into a metallic coil inside the ABC. The CO2 sampling tubes were positioned at the orifice of the left lower bronchus and the trachea, and the end-expiratory CO2 partial pressure (PET(CO2)) was measured. In the tPA group, blood flow at the left lower pulmonary artery (LL-flow) was improved to near baseline within approximately 30 min of receiving tPA, and PET(CO2) at the left lower bronchus (LL-PET(CO2)) increased in direct correlation with LL-flow. The hemodynamic improvement after tPA therapy correlated with the partial pressure of the regional pulmonary expiratory CO2. Moreover, it was suggested that changes in physiologic conditions in PTE were not determined by clot quantity alone. |
| Databáze: | OpenAIRE |
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