History of major depression is associated with neuropsychiatric symptoms but not systemic inflammation in a cross-sectional study in obese patients

Autor: Rocío Martín-Santos, Lison Huet, Eric Magne, Sandra Dexpert, Patrick Ledaguenel, G. Oriolo, Damien Forestier, Cédric Beau, Lucile Capuron
Přispěvatelé: Nutrition et Neurobiologie intégrée (NutriNeuro), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Service de Chirurgie Digestive et Pariétale, Clinique Tivoli Ducos [Bordeaux], Clinique Jean Villar
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
Cross-sectional study
[SDV]Life Sciences [q-bio]
vulnerability
Comorbidity
Systemic inflammation
Body Mass Index
Behavioral Neuroscience
0302 clinical medicine
Risk Factors
Prevalence
Depression (differential diagnoses)
2. Zero hunger
biology
major depressive disorder (MDD)
Depression
Mental Disorders
Middle Aged
3. Good health
C-Reactive Protein
Major depressive disorder
Female
France
medicine.symptom
Adult
medicine.medical_specialty
Immunology
03 medical and health sciences
Internal medicine
medicine
History of depression
Humans
Obesity
Inflammation
[SDV.GEN]Life Sciences [q-bio]/Genetics
Depressive Disorder
Major
Endocrine and Autonomic Systems
business.industry
C-reactive protein
medicine.disease
[SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics
030104 developmental biology
Cross-Sectional Studies
Case-Control Studies
biology.protein
neuropsychiatric symptoms
business
030217 neurology & neurosurgery
Zdroj: Brain, Behavior, and Immunity
Brain, Behavior, and Immunity, Elsevier, 2019, 76, pp.215-222. ⟨10.1016/j.bbi.2018.11.312⟩
ISSN: 1090-2139
0889-1591
DOI: 10.1016/j.bbi.2018.11.312⟩
Popis: International audience; Obesity is a major public health burden associated with neuropsychiatric comorbidities leading to social and occupational impairment. Given the growing prevalence of both obesity and mental disorders worldwide, understanding the risk factors of obesity-related neuropsychiatric comorbidities is crucial to develop preventive strategies and individualized treatments. Recent findings suggest that adiposity-driven inflammation contributes to neuropsychiatric comorbidities in obesity. However, not all obese subjects afflicted with chronic inflammation develop neuropsychiatric symptoms, suggesting additional risk factors. The aim of this study was to investigate the impact of personal history of major depressive disorder (MDD) on obesity-related inflammation and neuropsychiatric symptoms, and their relationship. A case-control study was conducted comparing 66 obese patients (body mass index > 35 kg/m(2)) and 22 healthy non-obese participants, free of any current neuropsychiatric diseases including MDD. Neuropsychiatric symptoms were assessed using the Neurotoxicity Rating Scale (NRS). Sociodemographic and clinical variables were gathered and blood was collected for the measurement of serum levels of high-sensitivity C-reactive protein (hs-CRP). Multiple regression analyses were performed to assess the contribution of obesity and personal history of MDD to clinical outcomes and inflammatory status in study participants. Hs-CRP levels as well as NRS scores were significantly increased in the obese group. Overall, personal history of depression accounted for increased NRS scores but no significant association was found with inflammatory status. In addition, history of depression did not significantly modulate the relationship of obesity-related inflammation with NRS scores. Interestingly, obese individuals with history of recurrent MDD (n = 13) exhibited higher scores in the cognitive and sickness symptoms dimensions of the NRS compared to obese subjects with history of one depressive episode only. Findings indicate that history of depression contributes to neuropsychiatric symptoms, but not to systemic inflammation, in obese subjects free of current depressive episode. These results provide relevant information on the risk factors that may help identify obese subjects with increased risk of neuropsychiatric comorbidity.
Databáze: OpenAIRE
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