Cyclooxygenase-2 expression in chronic liver disease and hepatocellular carcinoma: an immunohistochemical study
| Autor: | Ada Maria Florena, Lydia Giannitrapani, Luigi Sandonato, Natale D'Alessandro, Melchiorre Cervello, Emanuele La Spada, Sabrina Ingrao, Giuseppe Montalto, Maurizio Soresi |
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| Přispěvatelé: | GIANNITRAPANI L, INGRAO S, SORESI M, FLORENA AM, LA SPADA E, SANDONATO L, D'ALESSANDRO N, CERVELLO M, MONTALTO G, Giannitrapani, L, Ingrao, S, Soresi, M, Florena, AM, La Spada, E, Sandonato, L, D'Alessandro, N, Cervello, M, Montalto, G |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Carcinoma Hepatocellular Cirrhosis Population Biology medicine.disease_cause General Biochemistry Genetics and Molecular Biology Liver disease History and Philosophy of Science medicine Humans carcinogenesi education Aged education.field_of_study Liver Diseases General Neuroscience Liver Neoplasms Cyclooxygenase carcinogenesis liver disease Middle Aged medicine.disease Immunohistochemistry digestive system diseases Cyclooxygenase medicine.anatomical_structure Cyclooxygenase 2 Hepatocyte Hepatocellular carcinoma Chronic Disease biology.protein Female Carcinogenesis liver disease |
| Popis: | UNLABELLED Hepatocarcinogenesis is a multistep process characterized by hepatocyte inflammation, regeneration, and proliferation. These changes are believed to depend on the aberrant expression of various tumor suppressor genes, oncogenes and growth factors. Several studies have shown the involvement of cyclooxygenase-2 (COX-2), the inducible isoform of the enzymes that catalyze prostaglandin synthesis in various aspects of carcinogenesis. COX-2 has been described as being overexpressed in hepatocellular carcinoma (HCC) patients. Using immunohistochemistry, we studied COX-2 expression in different chronic liver diseases (CLD) including nonalcoholic steatohepatitis (NASH), chronic hepatitis (CH), liver cirrhosis (LC), and HCC in a population referred to a tertiary center in western Sicily, an area moderately endemic for CLD. Sixteen NASH, 35 CH, 15 LC, and 21 HCC samples were analyzed. Positive signs of COX-2 were observed in the cytoplasm of hepatocytes and median values were 6 (3-9) for NASH, 7 (3-9) for CH, 6 (4-9) for LC, and 4 (0-7) for HCC. COX-2 expression was significantly lower in HCC than in NASH (P < 0.001), CH (P < 0.0001), and LC (P < 0.0001). In HCC we found a wide range of COX-2 expression: from no expression in poorly differentiated areas to a high expression in well-differentiated ones, with an inverse correlation between COX-2 and tumor grading, according to Edmonson (rho=-0.67, P < 0.0001). IN CONCLUSION (a) COX-2 expression was significantly lower in HCC than in the other CLD; (b) COX-2 expression inversely correlated with tumor differentiation status. These results suggest that COX-2 expression could be related to the inflammatory phenomena present in the early phases of CLD and eventually to the induction of hepatocarcinogenesis. |
| Databáze: | OpenAIRE |
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