Platelet-rich plasma as a therapy for androgenic alopecia: a systematic review and meta-analysis
| Autor: | Salam Al Kassis, Adam Evans, Gabriella E. Glassman, Mirjana G Ivanic, Rand W. Pope, Mina A. Botros, F. Bennett Pearce, James M. Mwangi |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Dermatology Transplantation Autologous law.invention 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine Statistical significance medicine Humans Adverse effect 030203 arthritis & rheumatology Platelet-Rich Plasma business.industry Injection therapy Alopecia medicine.disease Treatment Outcome Systematic review Hair loss Meta-analysis Platelet-rich plasma Female business Hair |
| Zdroj: | Journal of Dermatological Treatment. 33:498-511 |
| ISSN: | 1471-1753 0954-6634 |
| DOI: | 10.1080/09546634.2020.1770171 |
| Popis: | Objective: The past decade has seen platelet-rich plasma (PRP) become a popular therapy around the world as a treatment for androgenetic alopecia (AGA). These systematic review and meta-analyses assess the effectiveness and adverse effects of PRP to determine the role of PRP as a treatment for AGA among the other non-surgical treatment modalities.Methods: This study follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and is registered under the PROSPERO ID CRD42019136329. Seven databases were searched from inception through May 2019. Meta-analyses of randomized controlled trials (RCTs) were performed to evaluate the effect of PRP treatments on hair density and hair thickness.Results: Thirty studies, including 687 patients, met our inclusion criteria. Twenty-nine studies reported beneficial results, and 24 studies reached statistical significance on a measured outcome. Ten RCTs were included. Our meta-analyses show that PRP treatment increases hair density and hair thickness.Conclusions: PRP is an autologous treatment that lacks serious adverse effects and effectively improves hair density and hair thickness in men and women with AGA. Future research should include low risk-of-bias RCTs to optimize treatment protocols, investigate variability among studies, and to obtain more data on hair thickness changes. |
| Databáze: | OpenAIRE |
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