Differential effects of antiepileptic drugs on neonatal outcomes
| Autor: | Kim J Meador, Joyce Liporace, Page B. Pennell, Michael Privitera, David W. Loring, Nancy Browning, Gus A. Baker, Jill Clayton-Smith, T. Crawford, Laura A. Kalayjian, A.M. Klein |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Phenytoin Pediatrics medicine.medical_specialty Lamotrigine Article Behavioral Neuroscience Epilepsy Pregnancy medicine Birth Weight Humans Retrospective Studies business.industry Infant Carbamazepine Odds ratio medicine.disease Neurology Premature birth Child Preschool Prenatal Exposure Delayed Effects Apgar Score Microcephaly Premature Birth Regression Analysis Small for gestational age Anticonvulsants Female lipids (amino acids peptides and proteins) Apgar score Neurology (clinical) Cognition Disorders business Head medicine.drug |
| Zdroj: | Epilepsy & Behavior. 24:449-456 |
| ISSN: | 1525-5050 |
| DOI: | 10.1016/j.yebeh.2012.05.010 |
| Popis: | Offspring of women with epilepsy (WWE) on AEDs are at increased risks for major congenital malformations and reduced cognition. They may be at risk for other adverse neonatal outcomes. Women with epilepsy on carbamazepine (CBZ), lamotrigine (LTG), phenytoin (PHT), or valproate (VPA) monotherapy were enrolled in a prospective, observational, multicenter study of the neurodevelopmental effects of AEDs. The odds ratio for small for gestational age (SGA) was higher for VPA vs. PHT, VPA vs. LTG, and CBZ vs. PHT. Microcephaly rates were elevated to 12% for all newborns and at 12 months old, but normalized by age 24 months. Reduced Apgar scores occurred more frequently in the VPA and PHT groups at 1 min, but scores were near normal in all groups at 5 min. This study demonstrates increased risks for being born SGA in the VPA and CBZ groups, and transiently reduced Apgar scores in the VPA and PHT groups. Differential risks among the AEDs can help inform decisions about AED selection for women during childbearing years. |
| Databáze: | OpenAIRE |
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