Spontaneous Axonal Dystrophy in the Brain and Spinal Cord in Naïve Beagle Dogs
| Autor: | Katherine Masek-Hammerman, Ingrid D. Pardo, Hayley N Ritenour, Diana Otis, Steven Bailey, Brad Bolon, Xavier Palazzi, Heather V. Dowty |
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| Rok vydání: | 2020 |
| Předmět: |
Central Nervous System
Male Pathology medicine.medical_specialty 040301 veterinary sciences Central nervous system Neuroaxonal Dystrophies Nerve fiber Toxicology Pathology and Forensic Medicine 0403 veterinary science 03 medical and health sciences Dogs medicine Animals Dog Diseases Molecular Biology 030304 developmental biology Medulla Oblongata 0303 health sciences business.industry Brain 04 agricultural and veterinary sciences Cell Biology Spinal cord Vagus nerve Disease Models Animal Lumbar Spinal Cord medicine.anatomical_structure Spinal Cord nervous system Peripheral nervous system Nerve Degeneration Female Sciatic nerve Cuneate nucleus business |
| Zdroj: | Toxicologic Pathology. 48:694-701 |
| ISSN: | 1533-1601 0192-6233 |
| Popis: | Axonal dystrophy (AD) is a common age-related neurohistological finding in vertebrates that can be congenital or induced by xenobiotics, vitamin E deficiency, or trauma/compression. To understand the incidence and location of AD as a background finding in Beagle dogs used in routine toxicity studies, we examined central nervous system (CNS) and selected peripheral nervous system (PNS) tissues in twenty 18- to 24-month-old and ten 4- to 5-year-old control males and females. Both sexes were equally affected. The cuneate, gracile, and cochlear nuclei and the cerebellar white matter (rostral vermis) were the most common locations for AD. Incidence of AD increased with age in the cuneate nucleus, cerebellar white matter (rostral vermis), trigeminal nuclei/tracts, and lumbar spinal cord. Axonal dystrophy in the CNS was not accompanied by neuronal degeneration/necrosis, nerve fiber degeneration, and/or glial reaction. Axonal dystrophy was not observed in the PNS (sciatic nerve, vagus nerve branches, or gastrointestinal mural autonomic plexuses). |
| Databáze: | OpenAIRE |
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