Role of HGF/c‐Met in the treatment of colorectal cancer with liver metastasis

Autor: Xiao‐jun Li, Xuejun Sun, Peihua Zhou, Li‐kun Yan, Xiao‐rong Wang, Guangbing Wei, Sai He, Jianfeng Yao, Jianbao Zheng, Li Zhang
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
Colorectal cancer
Health
Toxicology and Mutagenesis
Toxicology
Biochemistry
Receptor tyrosine kinase
annexin V‐FITC
Metastasis
chemistry.chemical_compound
0302 clinical medicine
Receptor
Research Articles
Aged
80 and over
biology
Hepatocyte Growth Factor
Liver Neoplasms
General Medicine
c‐Met RNA interference (RNAi)
Middle Aged
Proto-Oncogene Proteins c-met
Gene Expression Regulation
Neoplastic
Liver
030220 oncology & carcinogenesis
Lymphatic Metastasis
Molecular Medicine
Hepatocyte growth factor
Female
Colorectal Neoplasms
medicine.drug
Research Article
C-Met
hepatocyte growth factor (HGF)
03 medical and health sciences
Downregulation and upregulation
medicine
metastasis
Humans
Neoplasm Invasiveness
colorectal cancer (CRC) cell
Molecular Biology
neoplasms
Aged
Messenger RNA
030102 biochemistry & molecular biology
business.industry
medicine.disease
digestive system diseases
chemistry
biology.protein
Cancer research
business
Zdroj: Journal of Biochemical and Molecular Toxicology
ISSN: 1099-0461
1095-6670
Popis: The system of hepatocyte growth factor (HGF) and its receptor c‐Met plays a critical role in tumor invasive growth and metastasis. The mortality rate of colorectal cancer (CRC), one of the most commonly diagnosed malignancies, is increased by it gradual development into metastasis, most frequently in the liver. Overexpression of c‐Met, the protein tyrosine kinase receptor for the HCF/scatter factor, has been implicated in the progression and metastasis of human colorectal carcinoma. In this study, we aimed to investigate the role of c‐Met in CRC liver metastasis and illustrate the clinical impact of regulating HGF/c‐Met signaling in patients with CRC liver metastasis. We found that (I) higher levels of c‐Met expression (mRNA and Protein) in CRC liver metastasis than primary CRC by assessing the patient tissue samples; (II) a positive correlation of c‐Met expression with tumor stages of CRC liver metastasis, as well as c‐Met expression in CRC, live metastasis concurred with regional lymph node metastasis; (III) the clinical impact of downregulation of HGF/c‐Met signaling on the reduction of proliferation and invasion in CRC liver metastasis. Therefore, we demonstrate that the regulation of HGF/c‐Met pathways may be a promising strategy in the treatment of patients with CRC liver metastasis.
Databáze: OpenAIRE
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