Additional file 3 of Tumor-secreted exosomal miR-141 activates tumor-stroma interactions and controls premetastatic niche formation in ovarian cancer metastasis

Autor: Mo, Yulan, Leung, Leanne L., Mak, Celia S. L., Wang, Xueyu, Chan, Wai-Sun, Hui, Lynn M. N., Tang, Hermit W. M., Siu, Michelle K. Y., Sharma, Rakesh, Xu, Dakang, Tsui, Stephen K. W., Ngan, Hextan Y. S., Yung, Mingo M. H., Chan, Karen K. L., Chan, David W.
Rok vydání: 2023
DOI: 10.6084/m9.figshare.22604449
Popis: Additional file 3: Supplementary Figure S1. MiR-141 is an exosomal miRNA derived from ovarian cancer cells. Supplementary Figure S2. MiR-141 induces stromal fibroblasts to have CAF-like properties. Supplementary Figure S3. GROα is the major proinflammatory chemokine in miR-141- expressing stroma. Supplementary Figure S4. YAP1 of Hippo signaling is the direct target of miR-141. Supplementary Figure S5. Conditional knockout (cKO) of Yap1 in stroma promotes tumor dissemination. Supplementary Figure S6. Depletion of CXCR1/2 impairs the oncogenic potential of OvCa cells induced by GROα.-enriched CM.
Databáze: OpenAIRE