Oxygen-Releasing Antibacterial Nanofibrous Scaffolds for Tissue Engineering Applications
Autor: | Ahmed Alshahrie, Kalamegam Gauthaman, Sidi A. Bencherif, Adnan Memic, Tuerdimaimaiti Abudula, Ahmed H. Hammad, Kasturi Joshi Navare, Ali Tamayol |
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Rok vydání: | 2020 |
Předmět: |
oxygen-releasing scaffold
PGS/PCL calcium peroxide electrospinning biodegradability antibacterial properties biocompatibility Polymers and Plastics Biocompatibility Composite number 02 engineering and technology 010402 general chemistry 01 natural sciences Article lcsh:QD241-441 chemistry.chemical_compound lcsh:Organic chemistry Tissue engineering Calcium peroxide Mesenchymal stem cell General Chemistry Biodegradation 021001 nanoscience & nanotechnology Electrospinning 0104 chemical sciences chemistry Nanofiber 0210 nano-technology Biomedical engineering |
Zdroj: | Polymers, Vol 12, Iss 1233, p 1233 (2020) Polymers; Volume 12; Issue 6; Pages: 1233 Polymers |
ISSN: | 2073-4360 |
DOI: | 10.3390/polym12061233 |
Popis: | Lack of suitable auto/allografts has been delaying surgical interventions for the treatment of numerous disorders and has also caused a serious threat to public health. Tissue engineering could be one of the best alternatives to solve this issue. However, deficiency of oxygen supply in the wounded and implanted engineered tissues, caused by circulatory problems and insufficient angiogenesis, has been a rate-limiting step in translation of tissue-engineered grafts. To address this issue, we designed oxygen-releasing electrospun composite scaffolds, based on a previously developed hybrid polymeric matrix composed of poly(glycerol sebacate) (PGS) and poly(ε-caprolactone) (PCL). By performing ball-milling, we were able to embed a large percent of calcium peroxide (CP) nanoparticles into the PGS/PCL nanofibers able to generate oxygen. The composite scaffold exhibited a smooth fiber structure, while providing sustainable oxygen release for several days to a week, and significantly improved cell metabolic activity due to alleviation of hypoxic environment around primary bone-marrow-derived mesenchymal stem cells (BM-MSCs). Moreover, the composite scaffolds also showed good antibacterial performance. In conjunction to other improved features, such as degradation behavior, the developed scaffolds are promising biomaterials for various tissue-engineering and wound-healing applications. |
Databáze: | OpenAIRE |
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