Subgrouping of patients with oral lichen planus according to cytochrome P450 enzyme phenotype and genotype
| Autor: | Camilla Kragelund, K. Broesen, L. A. Torpet, Jesper Reibel, Siri Beier Jensen, C. Hansen Cand Scient |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male CYP2D6 medicine.medical_specialty Genotype Gastroenterology Pathology and Forensic Medicine Cytochrome P-450 CYP1A2 Risk Factors Internal medicine Humans Medicine Radiology Nuclear Medicine and imaging Dentistry (miscellaneous) CHRONIC HEPATITIS-C AUTOIMMUNE HEPATITIS CLINICAL-FEATURES DRUG ERUPTIONS LIVER FIBROSIS DISEASE AUTOANTIBODIES POLYMORPHISM ASSOCIATION PROGRESSION skin and connective tissue diseases Life Style Aged Aged 80 and over business.industry Life style CYP1A2 Middle Aged medicine.disease Phenotype stomatognathic diseases Cytochrome p450 enzyme Lifestyle factors Cytochrome P-450 CYP2D6 Immunology Female Surgery Oral lichen planus Oral Surgery business Lichen Planus Oral |
| Zdroj: | Kragelund, C, Jensen, S B, Scient, C H C, Brøsen, K, Torpet, L A & Reibel, J 2014, ' Subgrouping of patients with oral lichen planus according to cytochrome P450 enzyme phenotype and genotype ', Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, vol. 118, no. 4, pp. 469-474 . https://doi.org/10.1016/j.oooo.2014.06.008 |
| ISSN: | 2212-4403 |
| DOI: | 10.1016/j.oooo.2014.06.008 |
| Popis: | Objective This study aimed to determine if the activity of the environmentally influenced cytochrome P450 enzyme CYP1A2, alone or in combination with CYP2D6*4 genotype, discriminates subgroups of oral lichen planus (OLP) according to lifestyle factors and clinical manifestations. Study Design A total of 111 patients with OLP were categorized according to normal, low, or high CYP1A2 activity and CYP2D6*4 genotype. Lifestyle parameters influencing the CYP1A2 activity and symptoms and manifestations of OLP were recorded. Results Of the 111 patients, 21% had low, 65% normal, and 14% high CYP1A2 activity. The high-CYP1A2-activity group was more exposed to CYP1A2 inducers than the low-CYP1A2-activity group. In the normal-CYP1A2-activity group, more patients had a CYP2D6*4 genotype (58%) ( P = .02), and they presented more symptoms ( P = .003) and gingival lesions ( P = .03). More patients in the low-CYP1A2-activity group and without CYP2D6*4 genotype presented red lesions ( P = .04). Conclusions We suggest CYP2D6*4 genotype as a disease-susceptible genotype and low or high CYP1A2 activity levels as indicators of environmental influence in OLP subgroups. |
| Databáze: | OpenAIRE |
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