Elevated fecal calprotectin levels during necrotizing enterocolitis are associated with activated neutrophils extruding neutrophil extracellular traps

Autor: Christian C. Yost, J. Lowe, Phillip V. Gordon, Robert Schlaberg, Robert D. Christensen, Vickie L. Baer, Mark J. Cody, Diane K. Lambert, E Gerday, M J Sheffield, Brianna C. MacQueen, J G Shepherd
Rok vydání: 2016
Předmět:
0301 basic medicine
Pediatrics
Neutrophils
Pilot Projects
Infant
Premature
Diseases
calprotectin
Extracellular Traps
Severity of Illness Index
Gastroenterology
Feces
fluids and secretions
0302 clinical medicine
Infant
Very Low Birth Weight
Prospective Studies
digestive
oral
and skin physiology
hematochezia
Obstetrics and Gynecology
Gestational age
3. Good health
Necrotizing enterocolitis
Infant
Premature
NICU
medicine.medical_specialty
neutrophil extracellular traps
Article
03 medical and health sciences
Enterocolitis
Necrotizing
030225 pediatrics
Internal medicine
medicine
Humans
Maternal fetal
Neonatology
necrotizing enterocolitis
business.industry
Infant
Newborn
Neutrophil extracellular traps
medicine.disease
digestive system diseases
Radiography
030104 developmental biology
feeding intolerance
Case-Control Studies
Pediatrics
Perinatology and Child Health
neonate
Calprotectin
business
Leukocyte L1 Antigen Complex
Biomarkers
Zdroj: Journal of perinatology : official journal of the California Perinatal Association
ISSN: 1476-5543
0743-8346
DOI: 10.1038/jp.2016.105
Popis: BACKGROUND Neonates with necrotizing enterocolitis (NEC) have higher calprotectin levels in stool than do healthy neonates. However, it is not known whether high stool calprotectin at the onset of bowel symptoms identifies neonates who truly have NEC vs. other bowel disorders. STUDY DESIGN Neonates were eligible for this study when an x-ray was ordered to “rule-out NEC”. Stool calprotectin was quantified at that time and in a follow-up stool. Each episode was later categorized as NEC or not NEC. The location of calprotectin in the bowel was determined by immunohistochemistry. RESULTS Neonates with NEC had higher initial and follow-up stool calprotectin levels than did neonates without NEC. Calprotectin in bowel from neonates with NEC was within neutrophil extracellular traps (NETs). CONCLUSION At the onset of signs concerning for NEC, fecal calprotectin is likely to be higher in neonates with NEC. Calprotectin in their stools is exported from neutrophils via NETs.
Databáze: OpenAIRE
Externí odkaz: