IgG4-related disease: association between chronic rhino-sinusitis and systemic symptoms
| Autor: | Li Cui, Ming Zheng, Yanni Wang, Nan Chen, Yu-Tao Zhan, Zhengang Wang, Yuan Gao |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty China Eye Diseases Drug allergy Dermatitis Disease Drug Hypersensitivity 03 medical and health sciences 0302 clinical medicine Internal medicine parasitic diseases medicine Humans Sinusitis Glucocorticoids Asthma Rhinitis 030203 arthritis & rheumatology business.industry General Medicine Middle Aged medicine.disease Eosinophils Otorhinolaryngology 030220 oncology & carcinogenesis Case-Control Studies Immunoglobulin G Chronic Disease Histopathology IgG4-related disease Female Neurosurgery business Follow-Up Studies |
| Zdroj: | European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 275(8) |
| ISSN: | 1434-4726 |
| Popis: | The objective of this study is to analyze the relationship between chronic rhino-sinusitis (CRS) and systemic symptoms in patients with IgG4-related disease (IgG4-RD). The patients with IgG4-RD, confirmed by restrict association with clinical and histopathological manifestations between March 2013 and July 2016, were enrolled and followed-up for 1 year at the Tongren Hospital, Capital Medical University. The patients were divided into two groups: the case group included IgG4-RD patients with CRS confirmed by clinical and imaging, while the control group included IgG4-RD patients without CRS confirmed by clinical and imaging. Age, gender, clinical manifestations, the percentage of eosinophils in peripheral blood, sedimentation (ESR), C-reaction protein, serum IgE and IgG4 levels, histopathology, and treatment drugs at the baseline and 1 year of follow-up were compared between the two groups. A total of 46 cases met the diagnostic criteria for IgG4-RD. A total of 30 patients (65.2%) had IgG4-RD complicated with CRS, and were aged 49.7 ± 13.4 years, with male:female ratio = 2:1. The disease duration in the case group was longer than that in the control group (3.0 versus 0.8, p = 0.009). The ratio of ocular involvement was higher (86.7 versus 60%, p |
| Databáze: | OpenAIRE |
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