Carcinoid syndrome due to a malignant somatostatinoma
| Autor: | Erdoğan Sözüer, Ömer Özbakir, Tahir E. Patiroglu, Ali Ünal, Kadri Güven, Fahrettin Kelestimur, Figen Öztürk |
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| Jazyk: | angličtina |
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Pancreatic disease Antineoplastic Agents Hormonal Octreotide Internal medicine Somatostatinoma medicine Pancreatic polypeptide Humans Malignant Carcinoid Syndrome business.industry digestive oral and skin physiology Liver Neoplasms General Medicine Middle Aged medicine.disease Malignant Somatostatinoma Pancreatic Neoplasms medicine.anatomical_structure Endocrinology Female Pancreas business Carcinoid syndrome hormones hormone substitutes and hormone antagonists medicine.drug Research Article |
| Popis: | Somatostatinoma is one of the rarest tumours of the endocrine pancreas. Cardinal manifestations of a somatostatinoma include gallstones, mild diabetes mellitus, steatorrhoea, diarrhoea and dyspepsia. Like any other pancreatic islet cell carcinoma, a somatostatinoma may also produce several different hormones such as adrenocorticotropic hormone, calcitonin, vasoactive intestinal polypeptide, pancreatic polypeptide, gastrin, insulin, and glucagon. In many cases, the clinical picture is dominated by the effect of these other hormones. We present a patient with somatostatinoma in which an immunocytochemical study of the specimens from pancreas and liver showed a weak positive reaction for gastrin besides a strong positive reaction for somatostatin. Interestingly, this patient also showed the signs of carcinoid syndrome which was successfully treated with octreotide. |
| Databáze: | OpenAIRE |
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