Inulin-based glycopolymer: Its preparation, lectin-affinity and gellation property
| Autor: | Teruaki Hasegawa, Kento Akiyama, Haruka Abe, Yosuke Togashi, Kazumi Izawa |
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| Rok vydání: | 2013 |
| Předmět: |
Rutin
Glycopolymer Clinical Biochemistry Inulin Pharmaceutical Science Biochemistry Tosyl Compounds chemistry.chemical_compound Lectins Drug Discovery Organic chemistry Molecular Biology Fluorescent Dyes Drug Carriers biology Chemistry Organic Chemistry Chemical modification Lectin Galactosides Hydrogels Kinetics Spectrometry Fluorescence Alkynes Self-healing hydrogels biology.protein Drug release Molecular Medicine Fluorescein-5-isothiocyanate |
| Zdroj: | Bioorganic & Medicinal Chemistry. 21:2895-2902 |
| ISSN: | 0968-0896 |
| DOI: | 10.1016/j.bmc.2013.03.066 |
| Popis: | The glycopolymer composed of an inulin scaffold and pendent β-lactosides was developed from commercially available inulin through sequential chemical modification processes composed of tosylation, azidation, and the subsequent Huisgen cyclocoupling with an alkyne-terminated β-lactoside. The resultant inulin-based glycopolymer has unique dual affinity towards β-galactoside and α-glucoside specific lectins which is attributable to its pendent β-lactosides and terminal α-glucoside. Its gellation property was also accessed to find that the inulin-based glycopolymer forms hydrogels whose critical gellation concentration (CGC) was lower than that required for hydrogels made from native inulin. Drug release properties of the inulin-based glycopolymer were also discussed in this paper. |
| Databáze: | OpenAIRE |
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