Risk factors of pulmonary arterial hypertension in patients with systemic lupus erythematosus
| Autor: | Xiao Zhang, Yuan Feng, Yun-xia Lei, Riqiang Luo, Jieying Wang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Hypertension Pulmonary Patient characteristics 030204 cardiovascular system & hematology Pericardial effusion 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans Lupus Erythematosus Systemic In patient Risk factor skin and connective tissue diseases 030203 arthritis & rheumatology Pulmonary Arterial Hypertension High risk patients business.industry General Medicine medicine.disease Ribonucleoprotein antibody Antibodies Antinuclear Pediatrics Perinatology and Child Health Cardiology Anticardiolipin antibodies Cardiology and Cardiovascular Medicine Vasculitis business |
| Zdroj: | Cardiology in the young. 31(10) |
| ISSN: | 1467-1107 1047-9511 |
| Popis: | Objectives:Pulmonary arterial hypertension symptoms in systemic lupus erythematosus patients are non-specific and early diagnosis and intervention are challenging. It remains essential to explore risk factors for pulmonary arterial hypertension in systemic lupus erythematosus patients to identify high risk patients and allow intensive monitoring.Methods:From January 2010 to December 2018, 84 patients with systemic lupus erythematosus and pulmonary arterial hypertension and 160 patients with systemic lupus erythematosus but without pulmonary arterial hypertension were enrolled. Clinical manifestations and laboratory test results were compared between the two groups to identify predictors of pulmonary arterial hypertension. Candidate pulmonary arterial hypertension risk factors were further compared among systemic lupus erythematosus-pulmonary arterial hypertension patients with different characteristics.Results:Among collected patient characteristics, Raynaud’s phenomenon (OR 2.32, 95% CI: 1.17–4.61), digital vasculitis (OR 4.12, 95% CI: 1.48–11.49), pericardial effusion, pulmonary interstitial lesions, positive anti-u1 ribonucleoprotein antibodies, and positive anticardiolipin antibodies immunoglobulin G were associated with significantly higher risk of pulmonary arterial hypertension in systemic lupus erythematosus patients. Among these candidate risk factors, positive anti-u1 ribonucleoprotein antibody was independently associated with severe pulmonary arterial hypertension and more active disease. Digital vasculitis was independently associated with systemic lupus erythematosus alleviation, while pericardial effusion was associated with systemic lupus erythematosus deterioration. Pericardial effusion was associated with longer pulmonary arterial hypertension duration.Conclusion:The significant association between studied clinical and laboratory indicators and risk of pulmonary arterial hypertension, pulmonary arterial hypertension and systemic lupus erythematosus characteristics suggested that these factors can be used to identify patients at higher risk of pulmonary arterial hypertension and adverse outcomes. Close monitoring may be indicated in patients with these risk factors, especially with more than one risk factor. |
| Databáze: | OpenAIRE |
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