Alterations of the blood–brain barrier in cerebral white matter lesions in the ageing brain
| Autor: | George M. Savva, Carol Brayne, James R. Cooper, Gillian Forster, Lynne Baxter, Paul G. Ince, Julie E. Simpson, Pamela J. Shaw, Fiona E. Matthews, Catherine Gelsthorpe, Stephen B. Wharton |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Aging Pathology medicine.medical_specialty Central nervous system Biology Occludin Blood–brain barrier Nerve Fibers Myelinated Tight Junctions White matter Parenchyma medicine Humans Aged Aged 80 and over Cerebral Cortex General Neuroscience Cerebral Arteries Extravasation Hyperintensity Capillaries medicine.anatomical_structure Blood-Brain Barrier Ageing Female |
| Zdroj: | Neuroscience Letters. 486:246-251 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2010.09.063 |
| Popis: | White matter lesions (WML) are associated with dementia and are common in brain ageing. In order to determine whether alteration of the blood-brain barrier (BBB) may contribute to the pathogenesis of WML we assessed albumin leakage and expression of the tight junction (TJ) proteins claudin-5 (Cln-5), zona occludin-1 (ZO-1) and occludin in cases derived from the Medical Research Council Cognitive Function and Ageing Study. Albumin extravasation was widespread in the ageing brain and enhanced in WML, suggesting dysfunction of the BBB may contribute to the pathogenesis of WML. This was not accompanied by significant changes in the endothelial expression of TJ proteins. However, ZO-1 and occludin were expressed by glial cells throughout the parenchyma of both control white matter and WML, suggesting these TJ proteins may have other functions in the brain. |
| Databáze: | OpenAIRE |
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