Red blood cell distribution width (RDW) is an independent predictor of post-implantation syndrome in patients undergoing endovascular aortic repair for abdominal aortic aneurysm
| Autor: | Giuseppe Lippi, Paolo Criscenti, Gian Franco Veraldi, Fabio Simoncini, Luca Mezzetto, Marco Macrì, Chiara Bovo, Lorenzo Scorsone |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
endocrine system
medicine.medical_specialty complications medicine.medical_treatment Endovascular aneurysm repair Abdominal aortic aneurism (AAA) Coronary artery disease Internal medicine medicine Mean corpuscular volume red blood cell distribution width (RDW) medicine.diagnostic_test business.industry endovascular aneurysm repair (EVAR) Area under the curve virus diseases Retrospective cohort study Red blood cell distribution width General Medicine Odds ratio biochemical phenomena metabolism and nutrition medicine.disease Abdominal aortic aneurysm Cardiology Original Article business |
| Popis: | Background: This observational, retrospective study aims establishing the role of red blood cell distribution width (RDW) for identifying abdominal aortic aneurism (AAA) patients at risk of developing post-implantation syndrome (PiS) after endovascular aneurysm repair (EVAR). Methods: The study population consisted of all patients undergoing EVAR for AAA at the University Hospital of Verona (Italy), between June 1, 2016 and May 31, 2018. Blood samples for measuring hemoglobin, mean corpuscular volume (MCV) and RDW were collected at hospital admission and the day after EVAR. The primary endpoint was PiS development. Delta variations were calculated as the ratio between values measured after and before EVAR. Results: The final study population consisted of 124 patients (10 women and 114 men; median age, 75 years), 55 of whom developed PiS. In patients with or without PiS hemoglobin significantly decreased after EVAR, whilst RDW significantly increased in patients with PiS and decreased in those without. Age, sex, hypertension, diabetes and renal failure were similar in patients who developed PiS or not, whilst a positive history of coronary artery disease was more frequent in PiS patients. Although hemoglobin and MCV changes after EVAR did not differ in patients with or without PiS, delta RDW was higher in those with PiS. The rate of patients with delta RDW >1 was significantly higher in patients with PiS that in those without (61.8% vs. 34.8%; P=0.002). In multivariate analysis, delta RDW remained independently associated with PiS (β coefficient, 2.023; P=0.001). A delta RDW >1 after EVAR was associated with ~3-fold enhanced risk of PiS (odds ratio, 3.04; P=0.003) and exhibited a good prognostic performance (area under the curve, 0.69; P |
| Databáze: | OpenAIRE |
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