Diminished cerebral metabolic response to motor stimulation in schizophrenics: a PET study
| Autor: | Kenneth Alper, Alfred P. Wolf, Jonathan D. Brodie, Fritz A. Henn, Nora D. Volkow, Adam Wolkin, Stephen L. Dewey, Robert Cancro, Elsa J. Bartlett, Wilfried Guenther |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Blood Glucose Male Psychosis Central nervous system Thalamus Stimulation Deoxyglucose Serial Learning Basal ganglia medicine Humans Attention Pharmacology (medical) Biological Psychiatry Cerebral Cortex Brain Mapping Brain General Medicine Middle Aged medicine.disease Psychiatry and Mental health medicine.anatomical_structure Motor Skills Cerebral cortex Schizophrenia Mental Recall Arousal Energy Metabolism Psychology Neuroscience Tomography Emission-Computed |
| Zdroj: | European Archives of Psychiatry and Clinical Neuroscience. 244:115-125 |
| ISSN: | 1433-8491 0940-1334 |
| Popis: | Positron emission tomography (PET) and the deoxyglucose method were used to measure cerebral metabolism in 14 normals and 13 schizophrenics at rest and during performance of simple and complex finger-movement sequences. The normals, but not the schizophrenics, showed significant metabolic activation in mesial frontal and contralateral sensorimotor and premotor regions during the complex movement. The relative metabolism of schizophrenics was significantly lower than normal in frontal regions and higher than normal in thalamus and basal ganglia under all scanning conditions. The results suggest that schizophrenics may have a brain dysfunction which limits their capacity to produce a focal metabolic response to stimulation in several functionally distinct brain regions. |
| Databáze: | OpenAIRE |
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