Effect of Low-Molecular-Weight Heparin on Recombinant Tissue Plasminogen Activator-induced Thrombolysis in Canine Pulmonary Embolism
| Autor: | John Ducas, Shian Gu, Richard M. Prewitt, S. Ming Chan, Joel Werter |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Pulmonary and Respiratory Medicine
Time Factors medicine.drug_class medicine.medical_treatment Low molecular weight heparin Blood Pressure Atrial Function Right Pulmonary Artery Critical Care and Intensive Care Medicine Dogs Animals Medicine Thrombolytic Therapy Embolization Cardiac Output Infusions Intravenous Chemotherapy Dose-Response Relationship Drug business.industry Anticoagulant Respiratory disease Drug Synergism Heparin Thrombolysis Heparin Low-Molecular-Weight medicine.disease Recombinant Proteins Pulmonary embolism Tissue Plasminogen Activator Anesthesia Injections Intravenous Regression Analysis Pulmonary Embolism Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Chest. 100:464-469 |
| ISSN: | 0012-3692 |
| DOI: | 10.1378/chest.100.2.464 |
| Popis: | We employed a canine model of pulmonary embolism induced by radioactive blood clots to determine if low-molecular-weight heparin augments recombinant tissue plasminogen activator (rtPA)-induced thrombolysis. Following embolization, dogs were randomized: group 1 dogs received heparin; group 2 dogs received low-molecular-weight heparin; group 3 dogs received 1.5 mg/kg of rtPA over 45 minutes; group 4 dogs received rtPA 3 mg/kg over 45 minutes; and group 5 dogs received 1.5 mg/kg of rtPA plus low-molecular-weight heparin. Over three hours, little thrombolysis occurred in groups 1 and 2. In contrast, significant thrombolysis occurred in groups 3 to 5, 46 percent, 49 percent, and 46 percent, respectively (all p less than 0.01 compared with groups 1 and 2). We conclude that there is an upper limit to the dose-thrombolytic rate relationship with rtPA, and that low-molecular-weight heparin does not augment rtPA-induced thrombolysis. |
| Databáze: | OpenAIRE |
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