Chromosome analysis of workers occupationally exposed to radiation at the Sellafield nuclear facility
| Autor: | E. J. Tawn, S. D. Morris, D Holdsworth, Caroline A. Whitehouse, R E Tarone |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Lymphocyte Chromosome Breakpoints Occupational disease Physiology Chromosomal translocation Chromosome aberration Ionizing radiation Age Distribution Occupational Exposure Radiation Ionizing medicine Humans Radiology Nuclear Medicine and imaging Lymphocytes Cells Cultured In Situ Hybridization Fluorescence Aged Cell Nucleus Chromosome Aberrations Radiological and Ultrasound Technology business.industry Smoking Cytogenetics Dose-Response Relationship Radiation Middle Aged medicine.disease United Kingdom medicine.anatomical_structure Peripheral blood lymphocyte Cytogenetic Analysis Linear Models Nuclear medicine business Environmental Monitoring |
| Zdroj: | International Journal of Radiation Biology. 76:355-365 |
| ISSN: | 1362-3095 0955-3002 |
| DOI: | 10.1080/095530000138691 |
| Popis: | To investigate the relationship between stable chromosome aberration frequency in peripheral blood lymphocytes and occupational cumulative radiation exposure.Cytogenetic analysis using G-banding was performed on peripheral blood lymphocyte cultures from 104 workers from the British Nuclear Fuels PLC facility at Sellafield, UK. The study group comprised 61 men with lifetime cumulative doses500 mSv, 39 men with minimal exposure (i.e.50 mSv) who formed a control group and 4 men with intermediate doses.The slope of the dose-response, adjusted for smoking status, for translocations and insertions was 0.55+/-0.31 x 10(-2)/cell/Sv. Consideration of chromosome breakpoints for all aberrations combined in the radiation workers revealed an excess in the C group chromosomes and a deficit in the F group chromosomes with breakpoints being concentrated in the terminal regions whereas the distribution in the control group did not deviate from expectation.The dose-response was not significantly different from the parallel FISH analysis (Tucker et al. 1997) and confirms that chronic radiation exposure appears to be substantially less effective at inducing stable chromosome aberrations in comparison with acute exposure. |
| Databáze: | OpenAIRE |
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