Assignment of Ptprn2, the gene encoding receptor-type protein tyrosine phosphatase IA-2beta, a major autoantigen in insulin-dependent diabetes mellitus, to mouse chromosome region 12F
| Autor: | van den Maagdenberg Am, Bé Wieringa, Jan Schepens, Wiljan Hendriks, Pepers B, Schepens Mt, van Kessel Ag |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
DNA Complementary Protein tyrosine phosphatase Biology Autoantigens Mice Gene mapping Internal medicine Genetics medicine Animals Gene Symbol Molecular Biology Gene Genetics (clinical) Chromosome 12 In Situ Hybridization Fluorescence Protein Tyrosine Phosphatase Non-Receptor Type 1 Chromosome Mapping Protein phosphatase 2 Molecular biology Major gene Endocrinology Diabetes Mellitus Type 1 PTPRN2 Protein Tyrosine Phosphatases |
| Zdroj: | Cytogenetics and cell genetics. 82(3-4) |
| ISSN: | 0301-0171 |
| Popis: | The receptor-type protein tyrosine phosphatase IA-2β gene (mouse gene symbol Ptprn2) encodes a major autoantigen in insulin-dependent diabetes mellitus. We physically mapped Ptprn2 by fluorescence in situ hybridization to band F of mouse chromosome 12, a region that lacks diabetes susceptibility loci. The mapping confirms the proposed synteny of mouse 12F with band q36 of human chromosome 7. |
| Databáze: | OpenAIRE |
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