Medicinal Chemistry Perspective of Fused Isoxazole Derivatives
| Autor: | Prashant R. Murumkar, Mahesh A. Barmade, Mange Ram Yadav, Mayank Kumar Sharma |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Chemistry
Pharmaceutical Antineoplastic Agents 010402 general chemistry Ring (chemistry) 01 natural sciences Dicloxacillin Medicinal chemistry Structure-Activity Relationship chemistry.chemical_compound Central Nervous System Diseases Drug Discovery medicine Humans Hypoglycemic Agents Structure–activity relationship Organic chemistry Isoxazole Danazol chemistry.chemical_classification 010405 organic chemistry Biological activity Isoxazoles General Medicine 0104 chemical sciences chemistry Cardiovascular Diseases Azole Flucloxacillin medicine.drug |
| Zdroj: | Current Topics in Medicinal Chemistry. 16:2863-2883 |
| ISSN: | 1568-0266 |
| DOI: | 10.2174/1568026616666160506145700 |
| Popis: | Nitrogen containing heterocyclic rings with an oxygen atom is considered as one of the best combination in medicinal chemistry due to their diversified biological activities. Isoxazole, a five membered heterocyclic azole ring is found in naturally occuring ibetonic acid along with some of the marketed drugs such as valdecoxib, flucloxacillin, cloxacillin, dicloxacillin, and danazol. It is also significant for showing antipsychotic activity in risperidone and anticonvulsant activity in zonisamide, the marketed drugs. This review article covers research articles reported till date covering biological activity along with SAR of fused isoxazole derivatives. |
| Databáze: | OpenAIRE |
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