T-Cell Responses to Islet Antigens Improves Detection of Autoimmune Diabetes and Identifies Patients With More Severe β-Cell Lesions in Phenotypic Type 2 Diabetes
| Autor: | Harvey K. Chiu, Jamie Felton, Barbara Brooks-Worrell, Jerry P. Palmer, Amit Goel |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty T-Lymphocytes Endocrinology Diabetes and Metabolism medicine.medical_treatment T cell Type 2 diabetes Biology medicine.disease_cause Autoimmunity Islets of Langerhans Internal medicine Diabetes mellitus Internal Medicine medicine Humans Antigens Aged Autoantibodies Cell Proliferation Autoimmune disease geography geography.geographical_feature_category C-Peptide Insulin Autoantibody Fasting Middle Aged Glucagon medicine.disease Islet Diabetes Mellitus Type 1 Glucose Phenotype Endocrinology medicine.anatomical_structure Diabetes Mellitus Type 2 Immunology Female |
| Zdroj: | Diabetes. 56:2110-2115 |
| ISSN: | 1939-327X 0012-1797 |
| DOI: | 10.2337/db06-0552 |
| Popis: | Latent autoimmune diabetes in adults or type 1.5 diabetes is considered to be a T-cell–mediated autoimmune disease. However, identification of patients is based commonly on autoantibody (Ab) detection. To determine whether measuring T-cell reactivity to islet proteins compared with measuring Abs improves detection of autoimmune diabetes and how β-cell function correlates with T-cell reactivity compared with Ab positivity, we assessed the T-cell proliferative responses and Ab responses (islet cell autoantibodies, insulin autoantibodies, insulinoma-associated protein-2 autoantibodies, and GAD Abs) to islet proteins of 36 phenotypic type 2 diabetic patients. To be considered Ab+ or T-cell+, patients were required to be positive for a minimum of two consecutive time points. β-Cell function was measured with fasting and glucagon-stimulated C-peptide. Independent of T-cell reactivity, Ab+ and Ab− patients had comparable fasting and glucagon-stimulated C-peptide. Independent of Ab status, T-cell+ patients demonstrated significantly lower glucagon-stimulated (P < 0.003) C-peptide compared with T-cell− patients. These data suggest that measuring T-cell responses to multiple islet proteins in phenotypic type 2 diabetic patients improves identification of patients with autoimmune diabetes and delineates those who have a more severe β-cell lesion compared with Ab assessment alone. |
| Databáze: | OpenAIRE |
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