Nicaragua revisited: evidence of lower prevalence of chronic kidney disease in a high-altitude, coffee-growing village
| Autor: | Timothy S. Laux, Marvin González, Cecilia Torres Lacourt, Mark Unruh, Philip J. Bert, Aurora Aragón, Gerardo M Barreto Ruiz |
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| Rok vydání: | 2011 |
| Předmět: |
Gerontology
Adult Male Coffea Nicaragua Comorbidity Rural Health Kidney Risk Assessment Article Young Adult Altitude Sex Factors Risk Factors medicine Prevalence Albuminuria Humans Chi-Square Distribution business.industry Agriculture Middle Aged medicine.disease Health Surveys Cross-Sectional Studies Logistic Models Nephrology Creatinine Chronic Disease Lower prevalence Female Kidney Diseases business geographic locations Biomarkers Kidney disease Demography Glomerular Filtration Rate |
| Zdroj: | Journal of nephrology. 25(4) |
| ISSN: | 1724-6059 |
| Popis: | Chronic kidney disease (CKD) is found at epidemic levels in certain populations of the Pacific Coast in northwestern Nicaragua especially in younger men. There are knowledge gaps concerning CKD's prevalence in regions at higher altitudes.A cross-sectional study of adults between the ages of 20 and 60 years in 1 coffee-growing village in Nicaragua located at 1,000 m above sea level (MASL) altitude was performed. Predictors included participant sex, age, occupation, conventional CKD risk factors and other factors associated with CKD suggested by previous surveys in Central America. Outcomes included serum creatinine (SCr) values1.2 mg/dL for men and0.9 mg/dL for women, estimated glomerular filtration rate (GFR)60 ml/min per 1.73 m2, dipstick proteinuria stratified as microalbuminuria (30-300 mg/dL) and macroalbuminuria (300 mg/dL), hypertension and body mass index.Of 324 eligible participants, 293 were interviewed (90.4%), and 267 of those received the physical exam (82.4% overall). Of the sample, 45% were men. Prevalence rate of estimated GFR60 ml/min per 1.73 m2 was 0 for men (0%) and 2 for women (1.4%). The prevalence of at least microalbuminuria was significantly higher among men compared with women (27.5% vs. 21.4%, respectively; p=0.02).The CKD prevalence in this village is comparable to a previously studied Nicaraguan coffee-farming region and much lower than previously screened portions of northwestern Nicaragua. There is heterogeneity in CKD prevalence across Nicaragua. At this time, screenings should target individuals living in previously identified, higher risk regions. More work is needed to understand determinants of CKD in this resource-poor nation. |
| Databáze: | OpenAIRE |
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