Is it necessary for clinical tumor volume including neck muscles in target volume delineation of nasopharyngeal carcinoma?

Autor: Haixia Wu, Xiangquan Kong, Dan Zhao, Liqin Ma, Zhupeng Wu, Zhaodong Fei, Weining Fang, Fei Chen
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Laryngoscope Investigative Otolaryngology
Laryngoscope Investigative Otolaryngology, Vol 6, Iss 6, Pp 1353-1357 (2021)
ISSN: 2378-8038
Popis: Objectives To calculate the shrinkage of the neck muscles and dosimetric changes and to clarify the necessity of covering part of the muscle in neck node region delineation for patients with nasopharyngeal carcinoma (NPC) treated with intensity‐modulated radiotherapy. Methods In total, 44 patients with NPC were enrolled. Distances between the lateral border of the neck muscles and longitudinal midline were measured on every selected slice. This process was repeated three times, and the mean values of the three distances of planning computed tomography (CT) images and repeated CT images were adopted (labeled d1 and d2). The mean value of the differences between d1 and d2 was regarded as the medial shrinkage of the neck muscles. The initial clinical target volume of cervical lymph nodes (CTV‐n) was shifted medially with the value of shrinkage, yielding a new CTV‐n. Doses that covered 95% of the planning tumor volume (PTV) (D95), 99% of the PTV (D99), mean dose (Dmean), and maximum dose (Dmax) were used to calculate the dosimetric variation between the initial and new CTV‐n. Comparisons were performed using the paired samples t test. Results The median d1 was 3.81 cm (range: 1.19‐8.20 cm), and the median d2 was 3.68 cm (range: 0.94‐9.59 cm), with a statistically significant difference (P
Databáze: OpenAIRE
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