Kidins220 Correlates with Tau in Alzheimer’s Disease Brain and Cerebrospinal Fluid

Autor: Isidro Ferrer, Andrea Gamir-Morralla, Teresa Iglesias, Daniel Alcolea, A. Lleo, Juan Fortea, Olivia Belbin
Přispěvatelé: Universitat de Barcelona, Ministerio de Economía y Competitividad (España), Comunidad de Madrid, Instituto de Salud Carlos III, European Commission
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
Kidins220
Statistics as Topic
Cohort Studies
ARMS
0302 clinical medicine
antibody
Membrane proteins
Pathology
Medicine
Phosphorylation
Cervell
Aged
80 and over
Calpain
General Neuroscience
Proteïnes de membrana
Brain
General Medicine
Middle Aged
Alzheimer's disease
Patologia
Metabolisme
Psychiatry and Mental health
Clinical Psychology
Cerebrospinal fluid
Female
Alzheimer’s disease
Adult
Amyloid
Nerve Tissue Proteins
tau Proteins
tau protein
Antibodies
Necrosis
Young Adult
03 medical and health sciences
Regional development
Alzheimer Disease
mental disorders
Humans
Excitotoxicity
Aged
Tau protei
Amyloid beta-Peptides
business.industry
Líquid cefalorraquidi
Membrane Proteins
Peptide Fragments
Malaltia d'Alzheimer
Metabolism
030104 developmental biology
Phosphopyruvate Hydratase
Postmortem Changes
Geriatrics and Gerontology
business
Humanities
Biomarkers
030217 neurology & neurosurgery
Zdroj: Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Digital.CSIC. Repositorio Institucional del CSIC
JOURNAL OF ALZHEIMERS DISEASE
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
ISSN: 1875-8908
1387-2877
DOI: 10.3233/jad-160639
Popis: Identification of neurodegeneration-monitoring biomarkers would be of great clinical value for Alzheimer's disease (AD) diagnosis. Using N- or C-terminal antibodies, we studied the pro-survival synaptic effector, Kidins220, in the brain and cerebrospinal fluid (CSF) of controls and AD patients. Only the N-terminal antibody showed a positive correlation between Kidins220 and phosphorylated tau in AD brains. Using this antibody, Kidins220 was detected in CSF from AD patients where it positively correlated with CSF phosphorylated tau and tau. This study highlights the potential of Kidins220 as a CSF biomarker in AD.
T.I. is funded by SAF2014-52737-P (Ministerio de Economía y Competitividad, Spain), P2010/BMD-2331-Neurodegmodels (Comunidad de Madrid, Madrid, Spain); A.L. is funded by PI11/3035 and PI14/1561 provided by FEDER (European Funds for Regional Development) and Instituto de Salud Carlos III (Ministerio de Economía y Competitividad, Spain). T.I. and A.L. are also funded by Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) and CIBERNED cooperarive project 2013/07 (Instituto de Salud Carlos III, Ministerio de Economía y Competitividad, Spain). A.G.M is funded by a contract from CIBERNED-2013/07; O.B. is funded by the Miguel Servet Associate Investigator Project Grant (CP13/0091) and FIS (PI15/00058) provided by FEDER and Instituto de Salud Carlos III (Ministerio de Economía y Competitividad, Spain). The cost of this publication has been paid in part by FEDER funds.
Databáze: OpenAIRE
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