Evaluation of the dedicated Frontier coronary bifurcation stent: A matched pair analysis with drug-eluting and bare metal stents
| Autor: | Volkhard Kurowski, Franz Hartmann, Deepak Jain, Christina Thomsen, Anja Conrad, Peter W. Radke, Heribert Schunkert, Marko Remmel |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Matched Pair Analysis medicine.medical_specialty Paclitaxel medicine.medical_treatment Matched-Pair Analysis Lumen (anatomy) Antineoplastic Agents Coronary Angiography Blood Vessel Prosthesis Implantation Text mining Drug Delivery Systems medicine Bare metal Humans Prospective Studies Angioplasty Balloon Coronary Coronary bifurcation Aged Sirolimus medicine.diagnostic_test business.industry Coronary Stenosis Stent Drug-Eluting Stents General Medicine Equipment Design Middle Aged Blood Vessel Prosthesis Treatment Outcome Metals Angiography Female Radiology Cardiology and Cardiovascular Medicine business Mace |
| Zdroj: | Clinical research in cardiology : official journal of the German Cardiac Society. 97(4) |
| ISSN: | 1861-0684 |
| Popis: | Treatment of coronary bifurcation lesions (CBL) remains challenging. This study sought to evaluate a novel dedicated stent system (Frontier™ stent) by angiographic and clinical comparison with the provisional T-stenting technique using drug-eluting (DES) and bare metal stents (BMS). The study group comprised 105 CBL in 105 patients. 35 consecutive CBL were treated with the Frontier™ system. The control group of 70 CBL (35 DES, 35 BMS) was pair matched with the former group stratified by the type of CBL (Medina classification) and the reference diameter of the main branch (MB). Clinical, procedural, and quantitative angiographic data (QCA) were obtained in all patients. A follow-up angiography 6 ± 2-month post-index intervention was performed in 84/105 (80%) patients, clinical 6-month follow-up was available in all patients (100%). All Frontier™ stent procedures were clinically and angiographically successful. Post-procedural QCA analysis of the MB and the side branches revealed comparable minimal lumen diameters (MLDs) between groups. Moreover, contrast use and radiation exposure were not different between groups. DES use, however, was associated with a significantly lower late lumen (LL) loss in the main and the side branch as compared to the Frontier™ stent and BMS group. Likewise, MACE rates were lowest in the DES group (6%, P < 0.05 vs. BMS) as compared to the Frontier™ stent (9%) and the BMS group (16%). The Frontier™ stent accomplishes treatment of CBL with excellent acute clinical, procedural, and angiographic results. Provisional T-stenting using DES provides superior clinical and angiographic long-term results as compared to BMS and Frontier™ stents. The results of next generation CBL systems combining a dedicated specific CBL design with DES surfaces are to be awaited. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink