Platelet Surface CD62P and CD63, Mean Platelet Volume, and Soluble/Platelet P-Selectin as Indexes of Platelet Function in Atrial Fibrillation
| Autor: | Andrew D. Blann, Gregory Y.H. Lip, Irene Chung, Anirban Choudhury |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
P-selectin Heart disease business.industry Atrial fibrillation medicine.disease Platelet membrane glycoprotein Endocrinology Internal medicine medicine Cardiology Sinus rhythm Platelet Platelet activation Mean platelet volume business Cardiology and Cardiovascular Medicine |
| Zdroj: | Journal of the American College of Cardiology. 49(19):1957-1964 |
| ISSN: | 0735-1097 |
| DOI: | 10.1016/j.jacc.2007.02.038 |
| Popis: | Objectives The aim of this work was to comprehensively study the role of platelets in atrial fibrillation (AF), in relation to the underlying cardiovascular diseases and type of AF, and to analyze the effect of antithrombotic treatment on different aspects of platelet activation. Background Platelet activation is present in nonvalvular AF, but there is debate whether this is due to AF itself and/or to underlying cardiovascular diseases. Methods A total of 121 AF patients were compared with 65 “healthy control subjects” and 78 “disease control subjects” in sinus rhythm. Platelet activation was assessed using 4 different aspects of platelet pathophysiology: 1) platelet surface expression of CD62P (P-selectin) and CD63 (a lysosomal glycoprotein) (by flow cytometry); 2) mean platelet volume (MPV) (by flow cytometry); 3) plasma levels of soluble P-selectin (sP-selectin, enzyme-linked immunoadsorbent assay); and 4) total amount of P-selectin per platelet (pP-selectin) (“platelet lysis” assay). Results Both AF patients and “disease control subjects” had higher levels of CD62P (p Conclusions There is a degree of excess of platelet activation in AF compared with “healthy control subjects,” but no significant difference between AF patients and “disease control subjects” in sinus rhythm. Platelet activation may differ according to the subtype of AF, but this is not in excess of the underlying comorbidities that lead to AF. Platelet activation in AF may be due to underlying cardiovascular diseases, rather than due to AF per se. |
| Databáze: | OpenAIRE |
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