Not just vegetations: focal myocardial changes in patients with fungal infections
| Autor: | Nicole M. Cresalia, Gregory J. Ensing, Mark D. Norris, Sunkyung Yu, Terri Stillwell, Sonal T. Owens, Lauren Retzloff |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Scoring system Heart Valve Diseases Urine Gastroenterology Extracorporeal law.invention 03 medical and health sciences 0302 clinical medicine law Internal medicine medicine Humans In patient 030212 general & internal medicine Child Papillary muscle Retrospective Studies 0303 health sciences Endocarditis 030306 microbiology business.industry General Medicine Intensive care unit Catheter medicine.anatomical_structure Mycoses Case-Control Studies Pediatrics Perinatology and Child Health Thickening Cardiology and Cardiovascular Medicine business |
| Zdroj: | Cardiology in the young. 31(2) |
| ISSN: | 1467-1107 1047-9511 |
| Popis: | Background:Fungal endocarditis classically involves dense heterogenous vegetations. However, several patients with fungal infections were noted to have myocardial changes ranging from focal brightening to nodular thickening of chordae or papillary muscles. This study evaluates whether these findings are associated with fungal infections.Methods:In a retrospective case–control study, paediatric inpatients with fungal infections (positive blood, urine, or catheter tip culture) in a 5-year period were matched 1:1 to inpatients without positive fungal cultures. Echocardiograms were scored on a 5-point scale by two independent readers for presence of myocardial brightenings, nodular thickenings, and vegetations. Clinical data were compared.Results:Of 67 fungal cases, positive culture sites included blood (n = 44), vascular catheter tip (n = 7), and urine (n = 29); several had multiple positive sites. “Positive” echo findings (score ≥ 2+) were more frequent in the Fungal Group (33 versus 18%, p = 0.04). Fungal Group patients with “positive” versus “negative” echo findings had similar proportion of bacterial infections. Among fungal cases, those with “positive” echo findings had longer hospital length of stay than cases with “negative” echos (median 58 versus 40 days, p = 0.03) but no difference in intensive care unit admission, extracorporeal membranous oxygenation support, or mortality.Conclusions:Myocardial and papillary muscle brightening with nodular thickening on echocardiogram appear to be associated with fungal infections. There may be prognostic implications of these findings as patients with “positive” echo have longer length of stay. Further studies are needed to better understand the mechanism and temporal progression of these changes and determine the prognostic value of this scoring system. |
| Databáze: | OpenAIRE |
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