Long-term follow-up of hypopituitary patients treated with human growth hormone
| Autor: | Ann J. Johanson, Peter O. Kwiterovich, Samuel M. Libber, Claude J. Migeon, Robert M. Blizzard, Leslie P. Plotnick |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Thyroid Hormones Adolescent medicine.drug_class Pulsatile flow Physiology Thyroid Function Tests Thyroid function tests Hypopituitarism Testis Medicine Endocrine system Humans Testosterone Insulin-Like Growth Factor I medicine.diagnostic_test Anthropometry business.industry Human growth hormone Hypertriglyceridemia Ovary General Medicine Middle Aged medicine.disease Lipids Growth Hormone lipids (amino acids peptides and proteins) Female Adrenal Cortex Function Tests Gonadotropin business Lipoprotein |
| Zdroj: | Medicine. 69(1) |
| ISSN: | 0025-7974 |
| Popis: | Thirty-six former human growth hormone (hGH) recipients underwent comprehensive physical, endocrine and lipoprotein evaluations as adults. Treatment was associated with a decrease in height standard deviation score (SDS) in males from 4.0 pretreatment to 2.1 as adults, and in females from 4.2 to 2.5. Males showed a better growth response to treatment than did females. Plasma somatomedin-C levels were subnormal in 30 patients, but were higher in isolated growth-hormone-deficient patients than in others. Three men and 1 woman showed evidence suggesting a disturbance in pulsatile gonadotropin release despite the previous documentation of normal serum gonadotropin levels. Hypertriglyceridemia was not observed, and the women's plasma cholesterol levels were unremarkable. Men, however, showed higher-than-expected total cholesterol, LDL-cholesterol, and HDL-cholesterol concentrations. The last finding may explain the lack of increased cardiovascular morbidity in this group. |
| Databáze: | OpenAIRE |
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