Relative toxicity for indoor semi volatile organic compounds based on neuronal death

Autor: Emmanuel Baumont, Nathalie Bonvallot, Philippe Glorennec, Kevin Fournier
Přispěvatelé: Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Département Méthodes quantitatives en santé publique (METIS), Département Santé Environnement Travail et Génie Sanitaire (DSETGS), This work was supported by the French Ministry of Ecology: Primequal [Environnement Intérieur et Approches Innovantes], programme 190, THUR-BSAF action 13, sub-action 08, contract N°12-MRES-PRIMEQUAL-1-CVS-06., Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA)
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Time Factors
Diazinon
Relative toxicity
Benchmark concentrations
010501 environmental sciences
Biology
Toxicology
Risk Assessment
01 natural sciences
Locomotor activity
Semi volatile organic compounds
Cell Line
03 medical and health sciences
chemistry.chemical_compound
Toxicity Tests
medicine
Mixture
Humans
Viability assay
Indoor Air
0105 earth and related environmental sciences
Neurons
Air Pollutants
Inhalation Exposure
Volatile Organic Compounds
Models
Statistical
Cell Death
Dose-Response Relationship
Drug
Toxicity
Neurotoxicity
General Medicine
Pesticide
medicine.disease
Benchmarking
030104 developmental biology
chemistry
13. Climate action
Air Pollution
Indoor
Neurotoxicity Syndromes
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Exposure duration
Environmental Monitoring
Zdroj: Toxicology Letters
Toxicology Letters, 2017, 279, pp.33-42. ⟨10.1016/j.toxlet.2017.07.875⟩
Toxicology Letters, Elsevier, 2017, 279, pp.33-42. ⟨10.1016/j.toxlet.2017.07.875⟩
ISSN: 0378-4274
1879-3169
Popis: International audience; BACKGROUND: Semi Volatile Organic Compounds (SVOCs) are contaminants commonly found in dwellings as a result of their use as plasticizers, flame retardants, or pesticides in building materials and consumer products. Many SVOCs are suspected of being neurotoxic, based on mammal experimentation (impairment of locomotor activity, spatial learning/memory or behavioral changes), raising the question of cumulative risk assessment. The aim of this work is to estimate the relative toxicity of such SVOCs, based on neuronal death. METHOD: SVOCs fulfilling the following conditions were included: detection frequency >10% in dwellings, availability of data on effects or mechanism of action for neurotoxicity, and availability of dose-response relationships based on cell viability assays as a proxy of neuronal death. Benchmark concentration values (BMC) were estimated using a Hill model, and compared to assess relative toxicity. RESULTS: Of the 58 SVOCs selected, 28 were suspected of being neurotoxic in mammals, and 21 have been documented as inducing a decrease in cell viability in vitro. 13 have at least one dose-response relationship that can be used to derive a BMC based on a 10% fall in neuronal viability. Based on this in vitro endpoint, PCB-153 appeared to be the most toxic compound, having the lowest BMC10 (0.072μM) and diazinon the least toxic compound, having the highest BMC10 (94.35μM). We showed that experimental designs (in particular choice of cell lines) had a significant influence on BMC calculation. CONCLUSION: For the first time, the relative in vitro toxicity of 13 indoor contaminants belonging to different chemical families has been assessed on the basis of neuronal cell viability. Lack of comparable toxicity datasets limits the number of SVOCs that can be included. More standardized protocols in terms of cell lines, species and exposure duration should be developed with a view to cumulative risk assessment.
Databáze: OpenAIRE
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