Targeted Therapies for Eosinophilic Gastrointestinal Disorders
Autor: | Alfredo J. Lucendo, Piedad López-Sánchez |
---|---|
Rok vydání: | 2020 |
Předmět: |
Vedolizumab
03 medical and health sciences 0302 clinical medicine Adrenal Cortex Hormones Eosinophilic Eosinophilia Eosinophilic gastroenteritis Medicine Humans Pharmacology (medical) Eosinophilic esophagitis 030203 arthritis & rheumatology Pharmacology business.industry Interleukin General Medicine Atopic dermatitis Eosinophilic Esophagitis respiratory system medicine.disease Dupilumab Enteritis Clinical Trials Phase III as Topic 030220 oncology & carcinogenesis Gastritis Immunology business Janus kinase Biotechnology medicine.drug |
Zdroj: | BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. 34(4) |
ISSN: | 1179-190X |
Popis: | The growing recognition of eosinophilic gastrointestinal disorders has revealed the limitations of current treatment (mainly based on dietary modification and corticosteroids), and include refractoriness, high recurrence rates, and the need for long-term therapy. Research efforts, mainly in eosinophilic esophagitis (EoE), have unveiled essential pathophysiological mechanisms leading to these disorders, which bear some similarities to those of atopic manifestations and are shared by eosinophilic gastroenteritis (EGE) and eosinophilic colitis (EC). Novel targeted therapies, some imported from bronchial asthma and atopic dermatitis, are currently being assessed in EoE. The most promising are monoclonal antibodies, including those targeting interleukin (IL)-13 (cendakimab) and IL-4 (dupilumab), with phase 3 trials currently ongoing. The potential of anti-integrin therapy (vedolizumab) and Siglec-8 blockers (antolimab) in EGE are also promising. Non-biological therapies for eosinophilic gut disorders, which include preventing the activation of Janus kinase (JAK)-signal transducer and activator of transcription (STAT) and chemoattractant receptor expressed on T helper 2 cells (CRTH2) signaling pathways, and other potential targets that deserve investigation in eosinophilic gut disorders, are reviewed. |
Databáze: | OpenAIRE |
Externí odkaz: |