Designing an effective vaccine to prevent Epstein-Barr virus-associated diseases: challenges and opportunities
| Autor: | Corey Smith, Kunal H. Bhatt, Rajiv Khanna, Vijayendra Dasari |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Epstein-Barr Virus Infections Herpesvirus 4 Human Mononucleosis Lymphoma medicine.medical_treatment Immunology medicine.disease_cause Young adolescents Virus 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases Drug Discovery medicine Animals Humans Randomized Controlled Trials as Topic Pharmacology Nasopharyngeal Carcinoma biology business.industry Carcinoma Immune regulation Nasopharyngeal Neoplasms Viral Vaccines medicine.disease Epstein–Barr virus Disease Models Animal 030104 developmental biology 030220 oncology & carcinogenesis biology.protein Molecular Medicine Antibody business Adjuvant |
| Zdroj: | Expert review of vaccines. 16(4) |
| ISSN: | 1744-8395 |
| Popis: | Epstein-Barr virus (EBV) is a ubiquitous herpesvirus associated with a number of clinical manifestations. Primary EBV infection in young adolescents often manifests as acute infectious mononucleosis and latent infection is associated with multiple lymphoid and epithelial cancers and autoimmune disorders, particularly multiple sclerosis. Areas covered: Over the last decade, our understanding of pathogenesis and immune regulation of EBV-associated diseases has provided an important platform for the development of novel vaccine formulations. In this review, we discuss developmental strategies for prophylactic and therapeutic EBV vaccines which have been assessed in preclinical and clinical settings. Expert commentary: Major roadblocks in EBV vaccine development include no precise understanding of the clinical correlates of protection, uncertainty about adjuvant selection and the unavailability of appropriate animal models. Recent development of new EBV vaccine formulations provides exciting opportunities for the formal clinical assessment of novel formulations. |
| Databáze: | OpenAIRE |
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