Early detection of Pre-XDR TB with line probe assay in a high TB burden country

Autor: Jay Osi Samuels, Saheed Opeyemi Usman, Toyin Jolayemi, Laura Madukaji, Abubakar Usman, Uche Oyedum, Prosper Okonkwo, Femi Owolagba, AS Adedeji, Isaac Okohu, Abdullah Enagi, Eke Ofuche
Rok vydání: 2021
Předmět:
Zdroj: African Health Sciences; Vol. 21 No. 3 (2021); 968-974
ISSN: 1680-6905
DOI: 10.4314/ahs.v21i3.2
Popis: Background: Worldwide, tuberculosis (TB) is one of the top 10 causes of death. Drug resistant tuberculosis has lately become a major public health problem that threatens progress made in Tuberculosis (TB) care and control worldwide. The aim of this study was to determine the prevalence of Pre-extensive drug resistant TB among MDR TB in North Central of Nigeria. Methods: This study was conducted from October, 2018 to August, 2019 with 150 samples. In Nigeria, guidelines for DR-TB as recommended by WHO is followed. All the samples from the patients who gave their consent were transported to a zonal reference TB laboratory (ZRL). Results: Mean age was 38.6 ± 13.4 years with peak age at 35-44. Out of these 103 samples processed with LPA, 101(98%) were rifampicin resistant and 2 were rifampicin sensitive, 99(96%) were INH resistant and 4 (4%) were INH sensitive, 5(5%) were fluoroquinolone resistant, 98(95%) were fluoroquinolone sensitive, 12 (12%) were Aminoglycoside + Capreomycin resistant, 91(83%) were Aminoglycoside + Capreomycin sensitive. Conclusion: Multidrug resistant TB and its severe forms (Pre-extensive & extensively drug resistant TB) can be detected early with rapid tool- Line Probe Assay rapid and prevented timely by early initiation on treatment. Keywords: Pre-XDR TB; line probe assay in a high TB burden country.
Databáze: OpenAIRE
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