SEPT9 Mutations and a Conserved 17q25 Sequence in Sporadic and Hereditary Brachial Plexus Neuropathy
| Autor: | Diane M. Klein, Yanhong Wu, Peter J. Dyck, Christopher J. Klein, Scott M. Friedenberg, P. James B. Dyck, Anthony J. Windebank, Julie M. Cunningham |
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| Rok vydání: | 2009 |
| Předmět: |
Genetic Markers
Male DNA Mutational Analysis Hereditary neuralgic amyotrophy Biology medicine.disease_cause Article GTP Phosphohydrolases Conserved sequence Arts and Humanities (miscellaneous) medicine Humans Genetic Predisposition to Disease Genetic Testing Allele Brachial Plexus Neuropathies Cells Cultured Conserved Sequence Sequence (medicine) Genetics Mutation Base Sequence Chromosome Mapping medicine.disease Founder Effect Amino Acid Substitution Genetic marker North America Chromosomal region Female Neurology (clinical) Brachial plexus Septins Chromosomes Human Pair 17 |
| Zdroj: | Archives of Neurology. 66 |
| ISSN: | 0003-9942 |
| Popis: | Background The clinical characteristics of sporadic brachial plexus neuropathy (S-BPN) and hereditary brachial plexus neuropathy (H-BPN) are similar. During attacks, inflammation of the brachial plexus nerves has been identified in both conditions. SEPT9 mutations (Arg88Trp, Ser93Phe, 5′UTR c.-131G>C) occur in some families with H-BPN. These mutations were not found in North American kindreds with H-BPN with a conserved 500-kilobase sequence of DNA at the 17q25 chromosomal region (where SEPT9 localizes) where a founder mutation has been suggested. Objective To study the 17q25 sequence and SEPT9 in S-BPN (56 individuals) and H-BPN (13 kindreds). Methods Allele analysis at 17q25, SEPT9 DNA sequencing, and messenger RNA analysis from lymphoblast cultures were performed. Results A conserved 17q25 sequence was found in 5 of 13 kindreds with H-BPN and 1 individual with S-BPN. This conserved sequence was not found in the family with a SEPT9 mutation (Arg88Trp) or in 182 control subjects. SEPT9 messenger RNA expression levels did not differ between forms of H-BPN and control subjects. No known mutations of SEPT9 were found in S-BPN. Conclusions Rarely, individuals with S-BPN may have the same conserved 17q25 sequence found in many North American kindreds with H-BPN. Individuals with BPN with this conserved sequence do not seem to have SEPT9 mutations or alterations of messenger RNA expression levels in lymphoblast cultures and are predicted to have the most common genetic cause in North America by a founder-effect mutation. |
| Databáze: | OpenAIRE |
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