Choroidal Microvascular Dropout in Primary Angle Closure Glaucoma

Autor: Harsha L. Rao, Jayasree P. Venugopal, Shivani Dixit, Narendra K. Puttaiah, Robert N. Weinreb, Kaweh Mansouri, Carroll A.B. Webers, Zia S. Pradhan, Shruthi Sreenivasaiah, Mohammed Riyazuddin, Srilakshmi Dasari, Sathi Devi
Přispěvatelé: MUMC+: *MA Oogheelkunde (3), Oogheelkunde, MUMC+: MA UECM Oogartsen MUMC (9), RS: MHeNs - R3 - Neuroscience
Rok vydání: 2019
Předmět:
Male
Intraocular pressure
OPTICAL COHERENCE TOMOGRAPHY
genetic structures
Nerve fiber layer
Glaucoma
chemistry.chemical_compound
0302 clinical medicine
Prevalence
Prospective Studies
Fluorescein Angiography
Prospective cohort study
Peripheral Vascular Diseases
DAMAGE
0303 health sciences
DEFECTS
Middle Aged
ANGIOGRAPHY VESSEL DENSITY
medicine.anatomical_structure
PERIPAPILLARY RETINA
Female
Glaucoma
Angle-Closure
Glaucoma
Open-Angle
Tomography
Optical Coherence
medicine.medical_specialty
Optic Disk
Primary angle-closure glaucoma
Ciliary Arteries
Tonometry
Ocular
03 medical and health sciences
Ophthalmology
medicine
Humans
Intraocular Pressure
Aged
030304 developmental biology
Choroid
business.industry
Retinal
Optical coherence tomography angiography
Odds ratio
DISC PERFUSION
medicine.disease
eye diseases
Cross-Sectional Studies
SEVERITY
chemistry
Microvessels
030221 ophthalmology & optometry
Visual Field Tests
sense organs
Visual Fields
business
Zdroj: American Journal of Ophthalmology, 199, 184-192. Elsevier Science
ISSN: 0002-9394
DOI: 10.1016/j.ajo.2018.11.021
Popis: PURPOSE: To determine the prevalence and factors associated with the presence of choroidal microvascular dropout (CMvD) in primary angle-closure glaucoma (PACG) eyes compared to primary open-angle glaucoma (POAG) eyes.DESIGN: Cross-sectional study.METHODS: Thirty-six POAG eyes (36 patients) and 28 PACG eyes (28 patients) underwent optical coherence tomography angiography (OCTA). Presence of CMvD was evaluated on choroidal OCTA slabs. Visual field (VF) defects in the glaucoma eyes were classified into initial nasal defect (IND), initial parafoveal scotoma (IPFS), and combined nasal and parafoveal defect, and the association between type of VF defect and CMvD was evaluated.RESULTS: CMvD was detected in 21 POAG (58.3%) and 10 PACG (35.7%) eyes (P = .07). CMvD in POAG eyes was associated with pretreatment intraocular pressure (odds ratio [OR] = 0.91/mm Hg higher intraocular pressure, P = .06), VF mean deviation (MD, OR = 0.75/dB higher MD, P = .007), retinal nerve fiber layer thickness (OR = 0.92/mu m increase in thickness, P = .02), and peripapillary vessel density (OR = 0.80/ unit increase in density, P = .01). CMvD in PACG eyes was associated only with VF MD (OR = 0.90/dB higher MD, P = .05). When analyzed in the entire cohort of glaucoma patients (64 eyes), CMvD was significantly associated with POAG (OR > 3.5, P CONCLUSIONS: Prevalence of CMvD was significantly lower in PACG compared to POAG. As in POAG, CMvD in PACG was associated with advanced VF damage and with IPFS on VF. (C) 2018 Elsevier Inc. All rights reserved.
Databáze: OpenAIRE
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