Genetic variants in the SIRT6 transcriptional regulatory region affect gene activity and carcass quality traits in indigenous Chinese beef cattle (Bos taurus)
| Autor: | Yin-cang Han, Sayed Haidar Abbas Raza, Yonggang Sun, Irfan Ullah, Linsheng Gui, Matthew D. Garcia |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Genetic Markers Transcriptional Activation lcsh:QH426-470 lcsh:Biotechnology Gene Expression Single-nucleotide polymorphism Beef cattle Biology Fat deposition 03 medical and health sciences 0302 clinical medicine Quantitative Trait Heritable lcsh:TP248.13-248.65 Genetics SIRT6 Animals Sirtuins Expression pattern RNA Messenger Regulatory Elements Transcriptional Allele Promoter Regions Genetic Gene Alleles Genetic Association Studies Genetic association Haplotype Genetic Variation Promoter lcsh:Genetics Red Meat 030104 developmental biology Haplotypes Cattle Female DNA microarray Transcription factor 030217 neurology & neurosurgery Biotechnology Research Article |
| Zdroj: | BMC Genomics BMC Genomics, Vol 19, Iss 1, Pp 1-7 (2018) |
| ISSN: | 1471-2164 |
| Popis: | Background The aim of this study was to analyze potential influences of polymorphisms within the regulatory region of the bovine SIRT6 gene on carcass quality traits. Expression analyses suggested that SIRT6 gene is predominately expressed in kidney, compared with other tissues. In 535 indigenous Chinese beef cattle, two novel single nucleotide polymorphisms (SNPs) were identified within the promoter region of the SIRT6 gene. Results Association analysis indicated that G allele of the c.-1100 A > G had a positive effect on fat deposition, and the Hap4/4 diplotype had more favourable results than other dipoltypes with respect to the evaluation of carcass quality traits. Furthermore, promoter activity associated with the Hap3 haplotype was measured at higher levels than the Hap1 haplotype, which would be in agreement with the previously described association analysis. Conclusion The SIRT6 promoter variants significantly affect transcriptional levels and subsequently significantly influence bovine intramscular fat content. |
| Databáze: | OpenAIRE |
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