Heart rate variability in hyperthyroidism on sub Saharan African patients: a case–control study
| Autor: | Mesmin Dehayem, Marcel Azabji-Kenfack, Jean Claude Mbanya, Liliane Mfeukeu-Kuate, Eugene Sobngwi, Eliane Ngassam, Aurel T. Tankeu, C. Nganou-Gnindjio, Jean Claude Katte, Camille |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Sub saharan lcsh:Medicine Blood Pressure 030209 endocrinology & metabolism Continuous electrocardiogram 030204 cardiovascular system & hematology Autonomic Nervous System Hyperthyroidism General Biochemistry Genetics and Molecular Biology Electrocardiography 03 medical and health sciences 0302 clinical medicine Heart Rate Internal medicine Heart rate Humans Medicine Heart rate variability In patient lcsh:Science (General) lcsh:QH301-705.5 Africa South of the Sahara business.industry Short-term lcsh:R Case-control study General Medicine Middle Aged Research Note lcsh:Biology (General) Case-Control Studies Africa Cardiology Female Abnormal results business lcsh:Q1-390 |
| Zdroj: | BMC Research Notes BMC Research Notes, Vol 11, Iss 1, Pp 1-5 (2018) |
| ISSN: | 1756-0500 |
| Popis: | Objective We aimed to determine heart rate variability in freshly diagnosed untreated hyperthyroidism patients. We enrolled 10 patients (9 females) and 10 matched controls for sex and age. Each eligible patient underwent five different tests according to Ewing battery tests for cardiac autonomic dysfunction assessment. HRV was assessed during each maneuver and on 24 h using a continuous electrocardiogram with automatic estimation of SDNN, RMSSD, LF HF and HF/LH ratio. Results of tests were compared between hyperthyroidism patients and matched controls using the non-parametric test of Mann–Whitney. Results Heart rate was significantly higher in patients with thyrotoxicosis (82.91 ± 10.99 vs 67.04 ± 6.80; 0.006) compared to their controls. On time-domain analysis, there was a trend towards reduction in SDNN (39.52 vs. 63.75; p = 0.2) as well as the RMSSD (30.44 vs 64.03; p = 0.09) in patients with hyperthyroidism. The frequency-domain analysis showed non-significant higher values for the LF (43.87 vs 38.85 ± 12.85; p = 0.8) and lower for the HF (32.54 vs 43.39; p = 0.3). Test’s results were mostly impaired in hyperthyroid patients and all patients presented abnormal results for parasympathetic activity. Untreated and recently diagnosed hyperthyroidism is associated to an altered parasympathetic activity in sub Saharan African patients. |
| Databáze: | OpenAIRE |
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