The synergistic effect of sea cucumber saponins and caffeine on preventing obesity in high‐fat diet‐fed mice by extending the action duration of caffeine

Autor: Ying‐Cai Zhao, Le‐Ping Li, Xiao‐Yue Li, Cheng‐Cheng Wang, Jin‐Yue Yang, Chang‐Hu Xue, Yu‐Ming Wang, Tian‐Tian Zhang
Rok vydání: 2022
Předmět:
Zdroj: Journal of the Science of Food and Agriculture. 103:3950-3960
ISSN: 1097-0010
0022-5142
DOI: 10.1002/jsfa.12339
Popis: Sea cucumber saponins (SCSs) exhibit a unique structure and high bioactivities and might have specialized implications on caffeine metabolic process by altering the activity of N-demethylation enzyme CYP1A2. The present study aimed to clarify the effects of SCS on caffeine metabolism in vivo and in vitro, as well as the synergistic anti-obesity effect of SCS and caffeine on high-fat diet-induced obese mice.Results found that SCS administration significantly postponed the elimination rate of caffeine and its metabolites in vivo, and further study found CYP1A2-mediated caffeine metabolism was remarkably inhibited in a dose-dependent manner in vitro. The synergistic effect of the SCS and caffeine combination could decrease the total weight of white adipose tissue by 52% compared with high-fat diet-treated group.SCS could prolong caffeine action time, and the combination of the two substances exhibited joint action on high-fat diet-induced obese mice. These findings might provide a basis for the development of functional foods and potential application using the combination of SCS and caffeine. © 2022 Society of Chemical Industry.
Databáze: OpenAIRE
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