Synaptic Changes in Parkinson Disease Assessed with in vivo Imaging
| Autor: | Ivonne Suridjan, Mark Dias, Sjoerd J. Finnema, Nabeel Nabulsi, Yiyun Huang, David Matuskey, Kyle C. Wilcox, Takuya Toyonaga, Richard E. Carson, Jim Ropchan, Brian Pittman, Shannan Henry, Mika Naganawa, Sule Tinaz, Robert A. Comley |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Pathology medicine.medical_specialty Pyrrolidines Pyridines Red nucleus Nerve Tissue Proteins Substantia nigra Pathogenesis 03 medical and health sciences 0302 clinical medicine Dopamine Humans Medicine Research Articles Red Nucleus SV2A Membrane Glycoproteins business.industry Functional Neuroimaging Putamen Parkinson Disease Middle Aged 3. Good health Substantia Nigra Early Diagnosis 030104 developmental biology nervous system Neurology Case-Control Studies Positron-Emission Tomography Synapses Autoradiography Locus coeruleus Female Locus Coeruleus Neurology (clinical) Brainstem business 030217 neurology & neurosurgery Research Article medicine.drug |
| Zdroj: | Annals of Neurology |
| ISSN: | 1531-8249 0364-5134 |
| Popis: | Objective Parkinson disease is characterized by motor and nonmotor symptoms, reduced striatal dopamine signaling, and loss of dopamine neurons in the substantia nigra. It is now known that the pathological process in Parkinson disease may begin decades before the clinical diagnosis and include a variety of neuronal alterations in addition to the dopamine system. Methods This study examined the density of all synapses with synaptic vesicle glycoprotein 2A (SV2A) in Parkinson disease subjects with mild bilateral disease (n = 12) and matched normal controls (n = 12) using in vivo high‐resolution positron emission tomographic imaging as well as postmortem autoradiography in an independent sample with Parkinson disease (n = 15) and normal controls (n = 13) in the substantia nigra and putamen. Results A group‐by‐brain region interaction effect (F 10, 22 = 3.52, p = 0.007) was observed in the primary brain areas with in vivo SV2A binding. Post hoc analyses revealed that the Parkinson disease group exhibited lower SV2A in the substantia nigra (−45%; p |
| Databáze: | OpenAIRE |
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