Recent progress and new perspectives for diterpenoid biosynthesis in medicinal plants
| Autor: | Xiuyu Liu, Zhimin Hu, Juan Guo, Mei Tian, Baolong Jin, Wei Gao, Luqi Huang, Guanghong Cui, Ying Ma |
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| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
0303 health sciences Plants Medicinal Computational biology Biology Biosynthetic enzyme Biosynthetic Pathways Metabolic engineering 03 medical and health sciences Synthetic biology 0302 clinical medicine 030220 oncology & carcinogenesis Drug Discovery Humans Molecular Medicine Medicinal herbs Synthetic Biology Diterpenes Medicinal plants 030304 developmental biology Diterpenoid biosynthesis |
| Zdroj: | Medicinal Research Reviews. 41:2971-2997 |
| ISSN: | 1098-1128 0198-6325 |
| Popis: | Diterpenoids, including more than 18,000 compounds, represent an important class of metabolites that encompass both phytohormones and some industrially relevant compounds. These molecules with complex, diverse structures and physiological activities, have high value in the pharmaceutical industry. Most medicinal diterpenoids are extracted from plants. Major advances in understanding the biosynthetic pathways of these active compounds are providing unprecedented opportunities for the industrial production of diterpenoids by metabolic engineering and synthetic biology. Here, we summarize recent developments in the field of diterpenoid biosynthesis from medicinal herbs. An overview of the pathways and known biosynthetic enzymes is presented. In particular, we look at the main findings from the past decade and review recent progress in the biosynthesis of different groups of ringed compounds. We also discuss diterpenoid production using synthetic biology and metabolic engineering strategies, and draw on new technologies and discoveries to bring together many components into a useful framework for diterpenoid production. |
| Databáze: | OpenAIRE |
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