Terpene conjugates of diaminedichloridoplatinum(II) complexes: antiproliferative effects in HL-60 leukemia, 518A2 melanoma, and HT-29 colon cancer cells
| Autor: | Bernhard Biersack, Rainer Schobert, Günther Bernhardt, Susanne Bollwein, Miroslava Zoldakova |
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| Rok vydání: | 2008 |
| Předmět: |
Magnetic Resonance Spectroscopy
Time Factors Organoplatinum Compounds Stereochemistry Molecular Conformation Bioengineering HL-60 Cells Biochemistry Terpene chemistry.chemical_compound Structure-Activity Relationship medicine Tumor Cells Cultured Humans Molecular Biology Melanoma Cell Proliferation Cisplatin Dose-Response Relationship Drug Ligand Terpenes Stereoisomerism General Chemistry General Medicine Reference Standards medicine.disease Leukemia chemistry Molecular Medicine Growth inhibition Drug Screening Assays Antitumor HT29 Cells DNA Conjugate medicine.drug |
| Zdroj: | Chemistrybiodiversity. 5(8) |
| ISSN: | 1612-1880 |
| Popis: | Twenty-eight [6-(aminomethyl)nicotinate]dichloridoplatinum(II) complexes 1 esterified with various terpene alcohols either directly or via alkyl spacers were tested for antiproliferative activity in human 518A2 melanoma and HL-60 leukemia cells. Generally, conjugates with menthanes and polycyclic sesquiterpenes attached via propane-1,2-diyl spacers were most active. In the melanoma cells, the propane-1,2-diyl-spacered conjugates of (-)-menthol (1a(2')), (+)-neomenthol (1b(2')), (-)-carvomenthol (1h(2')), and (-)-isolongifolol (1n(2')) displayed growth inhibition at IC(50) |
| Databáze: | OpenAIRE |
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