Antioxidant micronutrients in children with thalassaemia in Egypt
| Autor: | Elgabry E, Shaker M, Ali S, Nasr Mr |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
Iron Overload Antioxidant Adolescent Iron medicine.medical_treatment Serum retinol Nutritional Status Physiology chemistry.chemical_element Antioxidants Selenium chemistry.chemical_compound Hospitals Urban medicine Humans Vitamin E Deficiency In patient Micronutrients Child Hospitals Teaching Serum ferritin Chelating Agents medicine.diagnostic_test Vitamin A Deficiency business.industry beta-Thalassemia Retinol Transfusion Reaction General Medicine Micronutrient Oxidative Stress Zinc Nutrition Assessment chemistry Case-Control Studies Child Preschool Ferritins Serum iron Egypt Female business Copper |
| Zdroj: | Eastern Mediterranean Health Journal. 8:490-495 |
| ISSN: | 1687-1634 1020-3397 |
| DOI: | 10.26719/2002.8.4-5.490 |
| Popis: | Repeated blood transfusions in patients with thalassaemia subject them to peroxidative tissue injury by secondary iron overload. To study the relationship between iron overload and antioxidant micronutrient status among children with thalassaemia, we measured serum levels of vitamins A and E, zinc, selenium, and copper in 64 children with beta-thalassaemia major and 63 age- and sex-matched controls. All of these elements were significantly lower in the thalassaemic children compared with controls. There was a highly significant inverse correlation between serum ferritin and serum retinol levels, and significant inverse correlations between serum iron and retinol and between serum iron and selenium. Serum ferritin showed a significant positive correlation with duration of chelation and transfusion treatments. Ways are needed to counteract this oxidative damage and its deleterious effect on the prognosis of thalassaemia. |
| Databáze: | OpenAIRE |
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