Semaphorins 3A and 7A: potential immune and neuroregenerative targets in multiple sclerosis
| Autor: | Carmen Espejo, Ana Gutiérrez-Franco, Herena Eixarch, Xavier Montalban |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
animal structures Multiple Sclerosis Central nervous system Disease Semaphorins Biology Immunomodulation Immune system Semaphorin medicine Animals Humans Molecular Biology Multiple sclerosis Experimental autoimmune encephalomyelitis Neurodegeneration Semaphorin-3A medicine.disease Neuroregeneration Axons Disease Models Animal medicine.anatomical_structure nervous system Immunology Molecular Medicine Neuroscience Signal Transduction |
| Zdroj: | Trends in molecular medicine. 19(3) |
| ISSN: | 1471-499X |
| Popis: | Semaphorins have been classically defined as axonal signalling cues involved in central nervous system (CNS) development, but in adults these molecules are expressed in distinct tissues and exert various functions under several physiological and pathological contexts. Semaphorins capable of modulating the immune system are particularly relevant in autoimmune diseases, especially multiple sclerosis (MS), which is a demyelinating, neurodegenerative disease. In this article, we compile recent insights into the specific roles of semaphorin (sema)3A and sema7A to clarify the details of their possible participation in the inflammatory and neurodegenerative phases of MS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect