In vitro activities of two new glycylcyclines, N,N-dimethylglycylamido derivatives of minocycline and 6-demethyl-6-deoxytetracycline, against 339 strains of anaerobic bacteria
| Autor: | Hannah M. Wexler, E Molitoris, Sydney M. Finegold |
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| Rok vydání: | 1994 |
| Předmět: |
Pharmacology
biology 6-demethyl-6-deoxytetracycline Tetracycline Clindamycin Minocycline biology.organism_classification In vitro Microbiology Anti-Bacterial Agents Metronidazole Bacteria Anaerobic Infectious Diseases Tetracyclines medicine Pharmacology (medical) Anaerobic bacteria Bacteria medicine.drug Research Article |
| Zdroj: | Antimicrobial agents and chemotherapy. 38(10) |
| ISSN: | 0066-4804 |
| Popis: | The in vitro activities of the N,N-dimethylglycylamido derivatives of minocycline (DMG-MINO) and 6-demethyl-6-deoxytetracycline (DMG-DMDOT) were compared with those of minocycline, tetracycline, clindamycin, and metronidazole by using the National Committee for Clinical Laboratory Standards-approved Wadsworth agar dilution method. The MICs of DMG-MINO, DMG-DMDOT, and metronidazole at which 90% of the strains were susceptible (0.5, 1, and 1 micrograms/ml, respectively) were lower than those for clindamycin, minocycline, and tetracycline (4, 8, and 32 micrograms/ml, respectively). All of the strains of anaerobes tested, except one strain of Bacteroides ovatus (MIC, 16 micrograms/ml), were susceptible to DMG-MINO and DMG-DMDOT at 8 micrograms/ml. |
| Databáze: | OpenAIRE |
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