Curcumin loaded nanocarriers obtained by self-assembly of a linear d,l-octapeptide-poly(ethylene glycol) conjugate

Autor: Anita Scipioni, Fabio Sciubba, Pasqualina Punzi, Valerio Viali, Cesare Giordano, Marco Diociaiuti, Federica Novelli, Giancarlo Masci, Stefano Morosetti, Serena De Santis
Přispěvatelé: Novelli, Federica, De Santis, Serena, Diociaiuti, Marco, Giordano, Cesare, Morosetti, Stefano, Punzi, Pasqualina, Sciubba, Fabio, Viali, Valerio, Masci, Giancarlo, Scipioni, Anita
Rok vydání: 2018
Předmět:
Circular dichroism
linear D
L octapeptide
Materials science
Polymers and Plastics
Curctunin drug release
General Physics and Astronomy
Nanoparticle
02 engineering and technology
010402 general chemistry
linear D
L octapeptide
peptide-poly(ethylene glycol) conjugate
self-assembly
rod-like nanoparticles
curcumin drug loading
curctunin drug release
01 natural sciences
curcumin drug loading
chemistry.chemical_compound
Dynamic light scattering
Curcumin drug loading
Materials Chemistry
Organic chemistry
curctunin drug release
Organic Chemistry
Self-assembly
self-assembly
Linear D
L octapeptide
021001 nanoscience & nanotechnology
Combinatorial chemistry
0104 chemical sciences
chemistry
Proton NMR
Curcumin
rod-like nanoparticles
Nanocarriers
peptide-poly(ethylene glycol) conjugate
0210 nano-technology
Peptide-poly(ethylene glycol) conjugate
Ethylene glycol
Rod-like nanoparticle
Conjugate
Zdroj: European Polymer Journal. 98:28-38
ISSN: 0014-3057
DOI: 10.1016/j.eurpolymj.2017.11.010
Popis: The preparation and characterization of a novel linear d , l -octapeptide-poly(ethylene glycol) conjugate, formulated as biocompatible nanocarrier of hydrophobic drugs, was reported. The PEGylated d , l -octapeptide was designed to self-assemble in core-shell nanoparticles with rod-like morphology obtained by exploiting the self-assembling properties of linear peptides with regularly alternating enantiomeric sequences in tubular structures. The conformational properties of the conjugate and its self-assembling capability were assessed through dynamic light scattering, energy filtered-transmission electron microscopy, scanning electron microscopy, circular dichroism, fluorescence, and proton nuclear magnetic resonance spectroscopy. Furthermore, the upload in peptide-polymer nanoparticles of curcumin, adopted as model of hydrophobic drugs, was performed. In fact, despite accumulating evidence suggests that curcumin has different therapeutic activities, its use in medicine is limited to the very low water solubility, low bioavailability and chemical instability. This work addresses such drawbacks showing that nanoparticles obtained by For-( d -Phe- l -Cys(Acm))4-NH-(CH2-CH2-O)45-CH3 self-assembly are effective carriers for curcumin with high drug loading and sustained drug release.
Databáze: OpenAIRE
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